11) Kwast and colleagues suggest there may be a subset of oncocytomas sharing the genetic and molecular features of chromophobe RCC
, thus explaining the rare occurrence of metastasis.
Based on biomarker analysis, we speculate that 5-fluorouracil, gemcitabine, or temozolomide might be active in advanced chromophobe RCC
because of the lack of expression of TS, RRM1, and MGMT, respectively," observed Philip Abbosh, M.
The Rosetta Kidney Cancer Test accurately classifies the four most common kidney tumors: clear cell renal cell carcinoma (RCC), papillary RCC, chromophobe RCC
The TMA also included 1 case of metastatic chromophobe RCC
and 1 case of unclassified RCC with matched primary tumor and metastasis, which showed no EZH2 labeling.
Distinguishing oncocytoma from RCC can be difficult, especially from chromophobe RCC
that shares similar histologic features and the granular cell type of clear-cell RCC.
Patients with Clear-Cell RCC have a poorer prognosis, and differences may also exist between the prognosis of patients with papillary and chromophobe RCC
Choueiri and colleagues (11) showed that patients with papillary RCC (PRCC) and chromophobe RCC
(ChRCC) may have prolonged progression-free survival (PFS) with sunitinib and sorafenib, although clinical responses remain overall low in PRCC.
27) Although relatively rare, patients with localized papillary and chromophobe RCC
can develop metastasis after nephrectomy, and IMP3 can be used to help identify subgroups of patients with high potential for developing metastases after surgery.
The Rosetta Kidney Cancer Test (TM) accurately classifies the four most common kidney tumors: clear cell renal cell carcinoma (RCC), papillary RCC, chromophobe RCC
We report a case of spontaneous necrosis of a primary chromophobe RCC
The single metastatic chromophobe RCC
was positive only for PAX8.
6) Chromophobe RCC
and oncocytoma are suspected to be closely related and are thought to show a similar distal tubular phenotype.