chromophobe renal cell carcinoma

(redirected from chromophobe RCC)

chromophobe renal cell carcinoma

a low-grade renal cell carcinoma composed of large polygonal cells with well-defined borders and amphophilic or pale cytoplasm. These cells grow in solid sheets, but focally they may form tubules, trabeculae, or cysts.

chromophobe renal cell carcinoma

An uncommon (4–5% of all renal tumours) renal cell carcinoma with relatively indolent growth and histologic changes of renal oncocytoma. It is thought to arise in the intercalated cells of the collecting ducts.

DiffDx
Oncocytoma, renal cell carcinoma—granular cell type.
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11) Kwast and colleagues suggest there may be a subset of oncocytomas sharing the genetic and molecular features of chromophobe RCC, thus explaining the rare occurrence of metastasis.
Based on biomarker analysis, we speculate that 5-fluorouracil, gemcitabine, or temozolomide might be active in advanced chromophobe RCC because of the lack of expression of TS, RRM1, and MGMT, respectively," observed Philip Abbosh, M.
The Rosetta Kidney Cancer Test accurately classifies the four most common kidney tumors: clear cell renal cell carcinoma (RCC), papillary RCC, chromophobe RCC and oncocytoma.
The TMA also included 1 case of metastatic chromophobe RCC and 1 case of unclassified RCC with matched primary tumor and metastasis, which showed no EZH2 labeling.
Distinguishing oncocytoma from RCC can be difficult, especially from chromophobe RCC that shares similar histologic features and the granular cell type of clear-cell RCC.
Patients with Clear-Cell RCC have a poorer prognosis, and differences may also exist between the prognosis of patients with papillary and chromophobe RCC (Non-Clear Cell).
Choueiri and colleagues (11) showed that patients with papillary RCC (PRCC) and chromophobe RCC (ChRCC) may have prolonged progression-free survival (PFS) with sunitinib and sorafenib, although clinical responses remain overall low in PRCC.
27) Although relatively rare, patients with localized papillary and chromophobe RCC can develop metastasis after nephrectomy, and IMP3 can be used to help identify subgroups of patients with high potential for developing metastases after surgery.
The Rosetta Kidney Cancer Test (TM) accurately classifies the four most common kidney tumors: clear cell renal cell carcinoma (RCC), papillary RCC, chromophobe RCC and oncocytoma.
We report a case of spontaneous necrosis of a primary chromophobe RCC.
The single metastatic chromophobe RCC was positive only for PAX8.
6) Chromophobe RCC and oncocytoma are suspected to be closely related and are thought to show a similar distal tubular phenotype.