chromophobe


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chromophobe

 [kro´mo-fōb]
any cell, structure, or tissue that does not stain readily; applied especially to the chromophobe cells of the anterior lobe of the pituitary gland.

chro·mo·phobe

(krō'mō-fōb),
Resistant to stains, staining with difficulty or not at all; denoting certain degranulated cells in the anterior lobe of the pituitary gland.
Synonym(s): chromophobic
[chromo- + G. phobos, fear]

chromophobe

/chro·mo·phobe/ (-fōb) any cell or tissue not readily stainable, such as the chromophobe cells in the adenohypophysis.

chromophobe

(krō′mə-fōb′) also

chromophobic

(-fō′bĭk)
adj.
Not staining readily with dye. Used of a cell or cell structure.

chromophobe

chro·mo·phobe

(krō'mō-fōb)
Resistant to stains, staining with difficulty or not at all; denoting certain degranulated cells in the anterior lobe of the pituitary gland.
Synonym(s): chromophobic.
[chromo- + G. phobos, fear]

chromophobe

Resistant to biological stains. This property can be an important distinguishing characteristic in identifying some cells. Chromophobe cells are those with granules that do not take up dyes.

chromophobe

any cell, structure or tissue that does not stain readily; applied especially to the chromophobe cells of the anterior lobe of the pituitary gland.

chromophobe adenoma
a nonfunctional pituitary tumor of the pars distalis is hormonally inactive but commonly causes clinical signs by compression of the pituitary gland and other nearby structures. Clinical signs include incoordination, weakness and exercise intolerance, muscle atrophy, sexual inactivity, blindness and dilatation and fixation of the pupils.
chromophobe carcinoma
rare nonfunctional pituitary tumors are usually large and invasive causing destruction of the pars distalis leading to panhypopituitarism and diabetes insipidus. There is extensive invasion of the brain and cranial bones, and metastases to spleen and liver and to regional lymph nodes may occur.
References in periodicals archive ?
In patients who are known or suspected to have Birt-Hogg-Dube syndrome, tumors with a mixture of oncocytoma and chromophobe renal cell carcinoma-like areas may also be diagnosed as hybrid oncocytic tumors.
3%) hybrid cases showing a mixed pattern of tumors in which three cases show a combination of clear cell with focal oncocytic pattern and papillary arrangement and one case revealing combination of clear cell with papillary arrangement with foci of chromophobe pattern.
At that time histology of the left kidney revealed a 165 mm chromophobe renal cell carcinoma which did not breach the renal capsule but did demonstrate vascular space invasion and renal sinus invasion.
WHO classification of renal tumours 2004 divides renal cell carcinomas into clear cell papillary chromophobe collecting duct of bellini medullary multilocular cystic translocation associated multilocular cystic after neuroblastoma mucinous tubular and spindle cell and unclassified types.
Previously, pathologic analysis could not distinguish a benign oncocytoma from a chromophobe subtype of RCC since oncocytic cells are seen in both lesions.
Ethnic group Histology 1 Caucasian/Asian Normal 2 Caucasian/Asian Normal 3 Caucasian/Asian Normal 4 Caucasian Normal 5 Caucasian Normal 6 Caucasian Normal 7 Caucasian/Asian Normal 8 Caucasian Normal 9 Caucasian Normal 10 Caucasian Normal 11 Caucasian Normal 12 Caucasian Normal 13 Caucasian Normal 14 Caucasian Squamous cell carcinoma 15 Caucasian Hepatocellular carcinoma 16 Caucasian Adenocarcinoma (various differentiation) 17 Caucasian Renal cell carcinoma (1 chromophobe, 1 clear cell type) 18 Caucasian Glioblastoma multiforme (n = 6); anaplastic astrocytoma (n = 2) Table 2.
Publication of a peer-reviewed article in the online version of the Journal of Molecular Diagnostics demonstrated the ability of microRNAs to accurately identify four histological types of renal tumors, namely clear cell, papillary and chromophobe renal cell carcinoma, as well as oncocytoma, a benign tumor.
Microsatellite allelotyping differentiates chromophobe renal cell carcinomas from renal oncocytomas and identifies new genetic changes.
6,7) PAX8 is positive in almost all RCCs, including clear cell RCC, papillary RCC, chromophobe RCC, sarcomatoid RCC, microphthalmia transcription factor (MiT) family translocation RCC, and mucinous tubular and spindle cell carcinoma (MTSC).
82 Papillary 178 (18%) 13 (18%) Chromophobe 64 (7%) 7 (10%) Others 70 (7%) 5 (7%) Unclassified 18 (2%) 2 (3%) Fuhrman grade, n (%) G1 132 (14%) 3 (4%) 0.
There is consensus that this grading system is applicable to clear cell and papillary RCC, but not to chromophobe RCC, since none of the grading systems provides prognostic information for chromophobe RCC.
Others have reported that patients with either papillary RCC or chromophobe RCC are more likely to have secondary colon cancer compared to patients with clear cell RCC; however, the literature lacks information regarding the histological subtype of RCC and synchronous gastrointestinal tumors [15].