KIF4A

(redirected from chromokinesin-A)

KIF4A

A gene on chromosome Xq13.1 that encodes an ATP-dependent, microtubule-based motor protein involved in the intracellular transport of membranous organelles. KIF4A translocates the protein regulator of cytokinesis 1 (PRC1) to the plus ends of interdigitating spindle microtubules during the metaphase-to-anaphase transition, which is an essential step in forming an organised central spindle midzone and midbody and in successful cytokinesis. KIF4A may play a role in mitotic chromosomal positioning and bipolar spindle stabilisation.