chromogranin A


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chromogranin A

A major protein in catecholamine storage vesicles (chromaffin granules) of the adrenal medulla, which is co-released therefrom with catecholamines by exocytosis.
 
Abnormal expression
Increased in anterior pituitary adenoma, parathyroid carcinoma, medullary thyroid carcinoma, carcinoid tumour, pancreatic islet cell tumour, small cell lung carcinoma.

Ref range
10–50 ng/mL.

chromogranin A

see parathyroid secretory protein.
References in periodicals archive ?
Plasma chromogranin A in pheochromocytoma, primary hyperparathyroidism and pituitary adenoma in comparison with catecholamine, parathyroid hormone and pituitary hormones.
Fragments of chromogranin A are present in the urine of patients with carcinoid tumors: development of a specific radioimmunoassay for chromogranin A and its fragments.
Chromogranin A (210-301) is the major form of pancreastatin-like material in human gut extracts and endocrine tumors.
Isolation of peptides arising from the specific posttranslational processing of chromogranin A and chromogranin B from human pheochromocytoma tissue.
Vasostatins, comprising the N-terminal domain of chromogranin A, suppress tension in isolated human blood vessel segments.
Chromogranin A peptide-specific antisera and high-performance size exclusion chromatography demonstrate amino-terminal and car boxy-terminal fragments of the native molecule in human cell lines.
Serum chromogranin A in the diagnosis and follow-up of neuroendocrine tumors of the gastroenteropancreatic tract.
Chromogranin A as serum marker for neuroendocrine neoplasia: comparison with neuron specific enolase and the a-subunit of glycoprotein hormones.