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A soluble and secretory hormone proteins of chromaffin granules. Chromogranins A, an acidic glycoprotein, comprises about 50% of the total protein of the granule matrix. Other types are chromogranin 13 and secretogranin II.
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In September 2001, the patient's serum serotonin and pancreatic polypeptide levels had risen even higher (1,386 ng/ml and 471 pg/ml, respectively), and his serum chromogranin A had more than tripled to 970 ng/ml (figure 4).
26) Ewing sarcoma is generally negative for CK20, chromogranin, and CD45.
26) Otherwise, up to 25% of NSCLCs show expression of neuroendocrine markers, such as chromogranin, synaptophysin, and CD56, and by definition, all large cell neuroendocrine carcinomas should have expression of a neuroendocrine marker, thus overlapping with SCLC.
Both NECs and paragangliomas stain for the neuroendocrine markers chromogranin and synaptophysin.
Most tumors were positive for one of the other markers: synaptophysin (6 of 7) and chromogranin (4 of 7).
Cytoplasmic neurosecretory granules are highlighted by immunostains for synaptophysin and chromogranin.
Merkel cell carcinoma is positive for neuroendocrine markers, such as synaptophysin and chromogranin, in most cases.
Immunohistochemical studies revealed diffuse strong reactivity for Melan-A (Figure, C), HMB-45 (Figure, D), smooth muscle actin (Figure, E), vimentin, and negative staining for inhibin, synaptophysin, chromogranin, calretinin, and AE1/3.
This virus, through a receptor-mediated process, selectively targets neuroendocrine tumor cells that express at least one of the following three biomarkers: synaptophysin, CD56, or chromogranin A.
In such a setting, immunohistochemistry analysis will help with the separation between primary and metastatic tumors: primary thyroid follicular tumors will usually be immunoreactive with thyroglobutin, CK7, and TTF-1, while C-cell--derived tumors will be reactive to calcitonin and chromogranin.
Synaptophysin, chromogranin, and somatostatin were positive in rare epithelial cells.
BAGNOLS-SUR-CEZE, France, September 23 /PRNewswire/ -- CISBIO Bioassays, a member of IBA group and a developer and marketer of diagnostic assays for the quantification of tumor markers, announced today the launch of its chromogranin A ELISA diagnostic tool, Chromoa.