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chromatolysis |
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chromatolysis /chro·ma·tol·y·sis/ (kro?mah-tol´i-sis) disintegration of Nissl bodies of a neuron as a result of injury, fatigue, or exhaustion.
chromatolysis 1. the solution and disintegration of the chromatin of cell nuclei. 2. disintegration of the Nissl bodies of a neuron as a result of injury, fatigue or exhaustion. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Beginning on day 5, however, neuronal degeneration was seen in many areas, manifested by shrinkage of the perikaryon with intense eosinophilia of the cytoplasm, central chromatolysis, and condensation of the nucleus. In the central nervous system, the neural cell body undergoes chromatolysis with peripheral shifting of the Nissl bodies (stocked metabolites) and a decrease in their number. This same drug also produced vestibulocochlear Wallerian-like degeneration and retinal ganglion cell chromatolysis in dogs treated for 14 weeks at 180 mg/kg/day, a dose that resulted in a mean plasma drug level similar to that seen with the 60 mg/kg/day dose. |
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