chromatin assembly factor-1

chromatin assembly factor-1

A protein encoded by CHAF1A on chromosome 19p13.3 that is critical for maintaining chromatin stability during DNA replication and repair.

Abnormal expression
CAF-1 is overexpressed in solid tumours—e.g., endometrium, uterine cervix, breast and renal. In most, CAF-1 overexpression is associated with a higher histologic grade and clinical stage, and is regarded as a predictor of adverse outcomes.
Mentioned in ?