choroideremia


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Related to choroideremia: gyrate atrophy

choroideremia

 [ko-roi″der-e´me-ah]
hereditary (X-linked) primary choroidal degeneration that, in males, eventually leads to blindness as degeneration of the retinal pigment epithelium progresses to complete atrophy; in females, it is nonprogressive and vision is usually normal.

cho·roi·der·e·mi·a

(kō-roy-der-ē'mē-ă), [MIM*303100]
Progressive degeneration of the choroid in males, occasionally in females, beginning with peripheral pigmentary retinopathy, followed by atrophy of the retinal pigment epithelium and of the choriocapillaris, night blindness, progressive constriction of visual fields, and finally complete blindness; X-linked inheritance caused by mutation in the Rab escort protein-1 (REP1) gene on Xq; heterozygous females show a pigmentary retinopathy but without visual defect or peripheral progression.
[choroid + G. erēmia, absence]

choroideremia

/cho·roid·er·e·mia/ (ko-roi″der-e´me-ah) an X-linked primary choroidal degeneration which, in males, eventually leads to blindness as degeneration of the retinal pigment epithelium progresses to complete atrophy; in females, it is nonprogressive and vision is usually normal.

choroideremia

[kôr′oidərē′mē·ə]
Etymology: Gk, chorion, skin + eidos, form + erēmia, destitution
hereditary primary degeneration of the retina, transmitted as an X-linked trait and beginning in the first decade of life. In males, the earliest symptom is usually night blindness, followed by constricted visual field and eventual blindness as the degeneration of the pigment epithelium of the retina progresses to complete atrophy. In females, it is nonprogressive; usually there is normal vision and often an atypical pigmentary retinopathy.

choroideremia

An X-linked recessive, MIM 303100 hereditary retinal degeneration (other hereditary retinal degenerations include Refsum’s disease, gyrate atrophy and abetalipoproteinemia), characterised by progressive centripetal loss of visual fields and depth perception due to degeneration of the choroid and retina. It is caused by mutation of the CHM (formerly, REP-1) gene on chromosome Xq21 that encodes component A of the RAB geranylgeranyl transferase holoenzyme, which binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction.

Pathogenesis
Blindness is due to degeneration of choriocapillaris, retinal pigment epithelium and photoreceptors.

choroideremia

Tapetochoroidal dystrophy A form of X-linked hereditary retinal degeneration–other hereditary retinal degenerations include Refsum's disease, gyrate atrophy and abetaipoproteinemia–characterized by a centripetal loss of visual fields due to a gene mutation in chromosome Xq21

cho·roi·der·e·mi·a

(kōr'oyd-ĕr-ē'mē-ă)
Progressive degeneration of the choroid in males, occasionally in females, beginning with peripheral pigmentary retinopathy, followed by atrophy of the retinal pigment epithelium and of the choriocapillaris, night blindness, progressive constriction of visual fields, and finally complete blindness; X-linked inheritance; heterozygous females show a pigmentary retinopathy but without visual defect or peripheral progression.
Synonym(s): progressive choroidal atrophy, progressive tapetochoroidal dystrophy.
[choroid + G.erēmia, absence]

choroideremia 

A bilateral, X-linked, recessive inherited degeneration of the choroid and retinal pigment epithelium characterized by night blindness (nyctalopia) which begins in early youth. Most males are myopic. The condition is mild and non-progressive in females. Both males and females display a salt and pepper appearance of the fundus, but in males it advances to complete atrophy and eventually blindness. Syn. progressive choroidal atrophy; progressive tapetochoroidal atrophy. See chromosome; inheritance.
References in periodicals archive ?
Started by Mark's parents, Angels for Mark has put on concerts, car shows and more to aid the efforts of the Choroideremia Research Foundation, which sees 94% of all funds raised going to research initiatives.
Following my diagnosis when I was five years old, my mum and my nan (pictured) set out on a mission to make others aware of choroideremia and, with the help of Fight for Sight, established a fund in my name--the Tommy Salisbury Choroideremia Fund.
Since then, together with the help of family, friends, colleagues and other families affected by choroideremia, they have raised more than 460,000 [pounds sterling] to help fund eye research into finding a cure for me and everyone who lives with this condition.
In partnership with Fight for Sight, the Tommy Salisbury Choroideremia Fund was established.
This enabled a collaboration between Professors Seabra and Robert MacLaren, at the University of Oxford, leading to the world's first gene therapy trial for choroideremia.
com 1,2,3,4,7,9 CHOROIDEREMIA See: Macular Diseases; Retinitis Pigmentosa; Visual Impairments CHRIST-SIEMENS-TOURAINE SYNDROME See: Craniofacial Disorders; Ectodermal Dysplasias CHROMOSOME 13 & 18 DISORDERS See also: Chromosome 18 Disorders SOFT Canada: Support Organization for Trisomy 18, 13 and Related Disorders 760 Brant St.
Success in 2014 shows no sign of slowing, with the publication of the initial results of the first gene-replacement clinical trial for choroideremia, which surpassed the expectations of researchers leading the study, gaining national press coverage in January.
We clearly started the year well," said Ms Acton, "with the results from the choroideremia trials being published in The Lancet.
Together they will fund new research grants which will finance research into retinitis pigmentosa, glaucoma, retinoblastoma, uveitis, nystagmus, choroideremia and thyroid eye disease.
THE FIRST clinical trial into the rare blinding condition choroideremia has started at Oxford Eye Hospital, thanks to a grant from Fight for Sight.