chorioepithelioma


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choriocarcinoma

 [kor″e-o-kahr″sĭ-no´mah]
a malignant neoplasm of trophoblastic cells formed by abnormal proliferation of the placental epithelium, without production of chorionic villi. It is a malignant variant of gestational thromboplastic disease and can occur following a full term pregnancy, pregnancy complicated by a mole, ectopic pregnancy, or abortion.

cho·ri·o·car·ci·no·ma

(kō'rē-ō-kar'si-nō'mă),
A highly malignant neoplasm derived from placental syncytial trophoblasts and cytotrophoblasts that forms irregular sheets and cords, which are surrounded by irregular "lakes" of blood; villi are not formed; neoplastic cells invade blood vessels. Hemorrhagic metastases develop relatively early in the course of the illness, and are frequently found in the lungs, liver, brain, and vagina, and various other pelvic organs; choriocarcinoma may follow any type of pregnancy, especially hydatidiform mole, and occasionally originates in teratoid neoplasms of the ovaries or testes.
Synonym(s): chorioepithelioma

chorioepithelioma

/cho·rio·epi·the·li·o·ma/ (kor″e-o-ep″ĭ-the″le-o´mah) choriocarcinoma.

chorioepithelioma

choriocarcinoma

Gynaecology
An aggressive, rapidly growing malignancy arising from trophoblastic tissue, either in a hydatidiform mole or de novo.
 
Epidemiology
More common in Asian women; average age, 31.

Clinical findings
Vaginal bleeding; with metastases to the lungs: haemoptysis, chest pain, shortness of breath.

Imaging
Multiple infiltrates of various size and shape.

Lab
Marked increase in beta-hCG.
 
Management
Methoterexate for early disease, EMACO (etoposide, methotrexate, actinomycin D, cyclosphosphamide, vincristine (oncovin)) for intermediate to advanced disease.

Prognosis
Generally excellent; up to 95% cure rate, even for cases with metastases.
 
Cause of death
Haemorrhage, pulmonary insufficiency, drug toxicity, sepsis, renal failure.
 
Thoracic surgery
Mediastinal choriocarcinomas are more common in young males, often associated with elevated hCG; they may cause gynaecomastia and impotence, and have a dismal prognosis.

cho·ri·o·car·ci·no·ma

(kō'rē-ō-kahr-si-nō'mă)
A highly malignant neoplasm derived from placental syncytial trophoblasts and cytotrophoblasts; villi are not formed; neoplastic cells invade blood vessels. Hemorrhagic metastases are found in the lungs, liver, brain, and vagina; choriocarcinoma may follow any type of pregnancy, especially one involving hydatidiform mole, and occasionally originates in teratoid neoplasms of the ovaries or testes.
Synonym(s): chorioepithelioma.

chorioepithelioma

choriocarcinoma.