chordoma

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Related to chordomas: chondrosarcomas

chordoma

 [kor-do´mah]
a malignant tumor arising in the axial skeleton from embryonic remains of the notochord.

chor·do·ma

(kōr-dō'mă), [MIM*215400]
A rare neoplasm of skeletal tissue in adults, derived from persistent portions of the notochord; composed of cells arranged in lobules, with abundant myxoid stroma; some cells contain vacuoles that resemble soap bubbles (physaliphorous cells); most frequently in the region of the clivus or lumbar-sacral cord.
[(noto)chord + G. -oma, tumor]

chordoma

/chor·do·ma/ (kor-do´mah) a malignant tumor arising from the embryonic remains of the notochord.

chordoma

[kôrdō′mə] pl. chordomas, chordomata,
a rare tumor that develops from the fetal notochord. It is usually located in the midline, behind the sella; it is slow growing but highly invasive.

chordoma

An encapsulated, locally invasive malignant tumour that arises from the foetal notochord in the sacrococcygeal and sphenooccipital regions.
 
Epidemiology
Predominantly in older (age 50–70) men for sacrococcygeal region and age 20–40 for sphenooccipital chordoma.
 
Management
Surgery, RT.
 
Prognosis
Recurrence is common, often years after adequate therapy.

chor·do·ma

(kōr-dō'mă)
A rare neoplasm of skeletal tissue in adults, derived from persistent portions of the notochord.
[(noto)chord + G. -oma, tumor]

chordoma

A slow-growing tumour of the spine arising from remnants of the primitive NOTOCHORD. Chordomas rarely spread remotely, but can cause severe local damage.

chordoma

a malignant tumor arising from embryonic remains of the notochord.
References in periodicals archive ?
16, 2012 /PRNewswire-USNewswire/ -- A genetic variation possessed by 40% of the population is associated with a five-fold increase in risk for developing chordoma, a cancer that strikes the bones of the skull and spine.
The biopsy revealed trabecular bone and marrow fat replaced by malignant tumour, in-keeping with chordoma, not the presumed diagnosis of renal cell carcinoma.
Expression of receptor tyrosine kinases (RTKs) and cell cycle proteins has also been studied in chordomas, with conflicting results.
Chordomas are bony tumors that are thought to arise from the remnants of the notochord, an embryologic structure that precedes the development of the axial skeleton.
Chordomas are slow growing and may reach considerable size before symptomatology leads to diagnosis.
3, 2012, the sinus trouble Pagan attributed to allergies was diagnosed as an extremely rare tumor, clival chordoma, at the base of his skull.
Immunohisto-chemical analysis can differentiate a chondrosarcoma from a chordoma; chondrosarcomas contain vimentin, and chordomas contain keratin.
Using the aforementioned criteria for surgical pathway recurrence, only two other cases of clival chordomas with surgical implantation to the neck fulfilling these criteria have been reported.
4 The specificity of this marker has been documented in only a handful of studies, comprising both intraaxial and extraaxial chordomas.
Chordomas are rare malignant neoplasms that arise from remnants of the embryological notochord.
Abstract: Although clival chordomas account for only a small percentage (0.
The ability of a combined therapy with aldoxorubicin and doxorubicin to demonstrate efficacy in this cancer at doses that were well-tolerated indicates its potential for the treatment of other chemotherapeutic-resistant tumors such as chondrosarcoma and chordomas.