One of the most common subtypes of gnathic osteosarcoma is chondroblastic osteosarcoma, which is made up of malignant, osteoid-producing cells with admixed islands and lobules of malignant cartilaginous or chondrosarcomatous
tissue (figure 2).
Sarcomatoid MMs usually consist of spindle cells but can be composed of lymphohistiocytoid cells and/or may also contain heterologous rhabdomyosarcomatous, osteosarcomatous, or chondrosarcomatous elements.
Secondary patterns of sarcomatoid MM may demonstrate anaplastic and giant cells with a differential diagnosis of high-grade sarcoma, osteosarcomatous areas with a differential diagnosis of osteosarcoma, or chondrosarcomatous areas with differential diagnosis of chondrosarcoma.
X * 10 letters: PAPALOAPAN, REMEMBERED, DISINHIBIT, MONOTROPOS (cham), ISOSTASIST (web2), TUMULTUOUS 11 letters: SANTALACEAE (dfpf), REPREHENDED, VIOLINISTIC, UNTENANTING, NON-ORTHODOX 12 letters: RHABARBARATE, PRETENSELESS, BIPINNATIFID, TRIVIALITIES, UNENLIVENING, PROTOBIOLOGY 13 letters: PAREIASAURIAN, PRINCIPIATION, GEOMORPHOLOGY 14 letters: HALICARNASSIAN (coll), SARRACENIACEAE (dfpf) PREVENTIVENESS, SPIRITUALIZING, UNENTERTAINING, ENDODONTOLOGIC 15 letters: PHARMACOMANIACS, INTERDEPENDENCY, UNINQUISITORIAL, UNCONDESCENDING, ISOCOTYLEDONOUS (dbs) 16 letters: TRANSCARBAMYLASE, SALICYLSALICYLIC, NEUROMUSCULATURE 18 letters: CHONDROSARCOMATOUS
, HYPERLEPTOPROSOPIC (d) Pattern * X ?
Foci of divergent differentiation are not uncommon, with rhabdomyosarcomatous, osteosarcomatous, chondrosarcomatous
, and angiosarcomatous elements appearing in some cases.
Pathologically, the differential diagnoses of osteoma include ossifying fibroma, osteoblastoma, osteosarcoma, and chondrosarcomatous
Here, we present one such case in which the tumor showed CRCC with extensive sarcomatoid changes containing heterologous elements in the forms of chondrosarcomatous and osteosarcomatous differentiation.
The sarcomatous element represented about 70% of the tumor, with 5% composed of osteosarcomatous and chondrosarcomatous components.
Although initial sections did not show a sarcomatous component, additional sections did reveal chondrosarcomatous
foci that were characterized by a chondroid matrix surrounding numerous atypical nuclei (figure 3).
Rhabdoid, rhabdomyosarcomatous, and chondrosarcomatous
components may be evident as well.
Secondary patterns of sarcomatoid MM may demonstrate anaplastic and giant cells with a differential diagnosis of malignant fibrous histiocytoma, osteosarcomatous areas with a differential diagnosis of osteosarcoma, or chondrosarcomatous
areas with a differential diagnosis of chondrosarcoma.
1 Adenocarcinoma with sarcomatous differentiation 2 2 Carcinoma with squamous cell and sarcomatous differentiation 2 17 Carcinoma with sarcomatous differentiation 3 18 Carcinoma with osteocartilagenous and rhabomyosarcomatous differentiation 4 19 Carcinoma with osteosarcomatous differentiation 4 32 Carcinoma with leiomyosarcomatous differentiation 6 33 Adenocarcinoma with osteosarcomatous and rhabdomyosarcomatous differentiation 7 37 Carcinoma with sarcomatous differentiation 8 51 Carcinoma with chondrosarcomatous
differentiation 11 52 Carcinoma with squamous cell and sarcomatous differentiation 12 * As shown in Table 1.