chondrosarcoma

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chondrosarcoma

 [kon″dro-sahr-ko´ma]
a malignant tumor derived from cartilage cells or their precursors.

chon·dro·sar·co·ma

(kon'drō-sar-kō'mă), [MIM*215300]
A malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and older people; most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion.

chondrosarcoma

/chon·dro·sar·co·ma/ (-sar-ko´ma) a malignant tumor derived from cartilage cells or their precursors.
central chondrosarcoma  one within a bone, usually not associated with a mass.

chondrosarcoma

[kon′drōsärkō′mə] pl. chondrosarcomas, chondrosarcomata
Etymology: Gk, chondros + sarx, flesh, oma, tumor
a malignant neoplasm of cartilaginous cells or their precursors that occurs most frequently in long bones, the pelvic girdle, and the scapula. The tumor is a large, smooth, lobulated growth composed of nodules of hyaline cartilage that may show slight to marked calcification. Also called chondroma sarcomatosum. chondrosarcomatous, adj.
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Chondrosarcoma

chondrosarcoma

A malignant mesenchymal tumour caused by the uncontrolled proliferation of chondroblasts. It is the second most common primary malignancy of bone after osteosarcoma and represents 25% of such lesions.

Epidemiology
Arise in the axial and proximal skeleton of adults and older people.

Clinical findings
Often asyptomatic initially; later, pain for months to years, swelling.

Imaging
MRI is the modality of choice; CT, plain films, show destructive, aggressive permeation of diaphysis by tumour.
 
DiffDx
Metastatic carcinoma, enchondroma, chondromyxoid fibroma.

Types
Clear cell, de-differented, extraskeletal mesenchymal, juxtacortical, mesenchymal, myxoid.

Prognosis
Grade 1, 88% 5-year survival; grade 3, 40% 5-year survival.

chon·dro·sar·co·ma

(kon'drō-sahr-kō'mă)
A malignant neoplasm derived from cartilage cells.

chondrosarcoma

A rare malignant tumour of the cartilaginous parts of bone affecting mainly the pelvis, ribs and breastbone (sternum) and causes a slowly expanding swelling. The outlook after surgical removal is usually favourable.

chondrosarcoma

malignant neoplasm of cartilage, arising near ends of long bones, talus or calcaneum; presenting in older adults and only rarely in children; characterized by dull pain and swelling, bone matrix calcification, endosteal scalloping, local cortical thinning and expansion and soft-tissue involvement; difficult to diagnose from radiographs (see Table 1)
Table 1: Tumours arising in bone
Bone tumour typeExamples occurring in lower limb/foot
BenignAneurysmal bone cyst
Solitary osteochondroma
Simple/solitary bone cyst
Osteoid osteoma
Giant-cell tumour
Enchondroma
Chondroblastoma
MalignantChondrosarcoma
Ewing's sarcoma
Osteogenic sarcoma

chon·dro·sar·co·ma

(kon'drō-sahr-kō'mă) [MIM*215300]
A malignant neoplasm derived from cartilage cells.

chondrosarcoma (kon´drōsärkō´mə),

n a malignant neoplasm composed of cartilage-like tissue.
n a malignant cartilage tumor primarily found in younger adults, usually located in or near the jaw.

chondrosarcoma

a malignant tumor derived from cartilage cells or their precursors.