chondrosarcoma

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chondrosarcoma

 [kon″dro-sahr-ko´ma]
a malignant tumor derived from cartilage cells or their precursors.

chon·dro·sar·co·ma

(kon'drō-sar-kō'mă), [MIM*215300]
A malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and older people; most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion.

chondrosarcoma

/chon·dro·sar·co·ma/ (-sar-ko´ma) a malignant tumor derived from cartilage cells or their precursors.
central chondrosarcoma  one within a bone, usually not associated with a mass.

chondrosarcoma

[kon′drōsärkō′mə] pl. chondrosarcomas, chondrosarcomata
Etymology: Gk, chondros + sarx, flesh, oma, tumor
a malignant neoplasm of cartilaginous cells or their precursors that occurs most frequently in long bones, the pelvic girdle, and the scapula. The tumor is a large, smooth, lobulated growth composed of nodules of hyaline cartilage that may show slight to marked calcification. Also called chondroma sarcomatosum. chondrosarcomatous, adj.
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Chondrosarcoma

chondrosarcoma

A malignant mesenchymal tumour caused by the uncontrolled proliferation of chondroblasts. It is the second most common primary malignancy of bone after osteosarcoma and represents 25% of such lesions.

Epidemiology
Arise in the axial and proximal skeleton of adults and older people.

Clinical findings
Often asyptomatic initially; later, pain for months to years, swelling.

Imaging
MRI is the modality of choice; CT, plain films, show destructive, aggressive permeation of diaphysis by tumour.
 
DiffDx
Metastatic carcinoma, enchondroma, chondromyxoid fibroma.

Types
Clear cell, de-differented, extraskeletal mesenchymal, juxtacortical, mesenchymal, myxoid.

Prognosis
Grade 1, 88% 5-year survival; grade 3, 40% 5-year survival.

chon·dro·sar·co·ma

(kon'drō-sahr-kō'mă)
A malignant neoplasm derived from cartilage cells.

chondrosarcoma

A rare malignant tumour of the cartilaginous parts of bone affecting mainly the pelvis, ribs and breastbone (sternum) and causes a slowly expanding swelling. The outlook after surgical removal is usually favourable.

chondrosarcoma

malignant neoplasm of cartilage, arising near ends of long bones, talus or calcaneum; presenting in older adults and only rarely in children; characterized by dull pain and swelling, bone matrix calcification, endosteal scalloping, local cortical thinning and expansion and soft-tissue involvement; difficult to diagnose from radiographs (see Table 1)
Table 1: Tumours arising in bone
Bone tumour typeExamples occurring in lower limb/foot
BenignAneurysmal bone cyst
Solitary osteochondroma
Simple/solitary bone cyst
Osteoid osteoma
Giant-cell tumour
Enchondroma
Chondroblastoma
MalignantChondrosarcoma
Ewing's sarcoma
Osteogenic sarcoma

chon·dro·sar·co·ma

(kon'drō-sahr-kō'mă) [MIM*215300]
A malignant neoplasm derived from cartilage cells.

chondrosarcoma (kon´drōsärkō´mə),

n a malignant neoplasm composed of cartilage-like tissue.
n a malignant cartilage tumor primarily found in younger adults, usually located in or near the jaw.

chondrosarcoma

a malignant tumor derived from cartilage cells or their precursors.
References in periodicals archive ?
Four out of seven patients with Maffucci syndrome developed other malignancies in addition to chondrosarcomas.
Temporal bone chondrosarcomas have been mistaken for multiple sclerosis, glomus jugulare tumors, meningiomas, and chordomas.
Many intraosseous processes contain mucin (chondromyxoid fibroma and chondrosarcoma, to name a few).
75% of chest wall chondrosarcomas arise from the costochondral junction between the ribs and sternum as was observed in our case.
Extraskeletal myxoid chondrosarcoma is a rare tumour, accounting for about 2.
Higher-grade chondrosarcomas contain relatively less extensive chondroid matrix.
Chondrosarcoma and the majority of soft-tissue sarcomas are resistant to chemotherapy, limiting effective treatment of metastases.
He told her she had a cancerous Cranial Chondrosarcoma and it was embracing so many nerve endings that it was causing numbness, loss of hearing, taste and smell.
The California group's successes have come with eye cancers and chondrosarcomas that envelop three sides of the spinal cord.
Beyond pancreatic cancer, we are focused on advancing IPI-926 in Phase 2 trials in myelofibrosis and chondrosarcoma, as well as exploring a range of indications through investigator sponsored trials.
Enchondromas may be difficult to discriminate from low-grade chondrosarcomas, but the latter is more likely in a history of pain, cortical destruction or soft tissue extension.
This is seen in lesions such as enchondroma and chondrosarcomas.