chondrosarcoma


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Related to chondrosarcoma: osteosarcoma, mesenchymal chondrosarcoma

chondrosarcoma

 [kon″dro-sahr-ko´ma]
a malignant tumor derived from cartilage cells or their precursors.

chon·dro·sar·co·ma

(kon'drō-sar-kō'mă), [MIM*215300]
A malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and older people; most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion.

chondrosarcoma

/chon·dro·sar·co·ma/ (-sar-ko´ma) a malignant tumor derived from cartilage cells or their precursors.
central chondrosarcoma  one within a bone, usually not associated with a mass.

chondrosarcoma

[kon′drōsärkō′mə] pl. chondrosarcomas, chondrosarcomata
Etymology: Gk, chondros + sarx, flesh, oma, tumor
a malignant neoplasm of cartilaginous cells or their precursors that occurs most frequently in long bones, the pelvic girdle, and the scapula. The tumor is a large, smooth, lobulated growth composed of nodules of hyaline cartilage that may show slight to marked calcification. Also called chondroma sarcomatosum. chondrosarcomatous, adj.
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Chondrosarcoma

chondrosarcoma

A malignant mesenchymal tumour caused by the uncontrolled proliferation of chondroblasts. It is the second most common primary malignancy of bone after osteosarcoma and represents 25% of such lesions.

Epidemiology
Arise in the axial and proximal skeleton of adults and older people.

Clinical findings
Often asyptomatic initially; later, pain for months to years, swelling.

Imaging
MRI is the modality of choice; CT, plain films, show destructive, aggressive permeation of diaphysis by tumour.
 
DiffDx
Metastatic carcinoma, enchondroma, chondromyxoid fibroma.

Types
Clear cell, de-differented, extraskeletal mesenchymal, juxtacortical, mesenchymal, myxoid.

Prognosis
Grade 1, 88% 5-year survival; grade 3, 40% 5-year survival.

chon·dro·sar·co·ma

(kon'drō-sahr-kō'mă)
A malignant neoplasm derived from cartilage cells.

chondrosarcoma

A rare malignant tumour of the cartilaginous parts of bone affecting mainly the pelvis, ribs and breastbone (sternum) and causes a slowly expanding swelling. The outlook after surgical removal is usually favourable.

chondrosarcoma

malignant neoplasm of cartilage, arising near ends of long bones, talus or calcaneum; presenting in older adults and only rarely in children; characterized by dull pain and swelling, bone matrix calcification, endosteal scalloping, local cortical thinning and expansion and soft-tissue involvement; difficult to diagnose from radiographs (see Table 1)
Table 1: Tumours arising in bone
Bone tumour typeExamples occurring in lower limb/foot
BenignAneurysmal bone cyst
Solitary osteochondroma
Simple/solitary bone cyst
Osteoid osteoma
Giant-cell tumour
Enchondroma
Chondroblastoma
MalignantChondrosarcoma
Ewing's sarcoma
Osteogenic sarcoma

chon·dro·sar·co·ma

(kon'drō-sahr-kō'mă) [MIM*215300]
A malignant neoplasm derived from cartilage cells.

chondrosarcoma (kon´drōsärkō´mə),

n a malignant neoplasm composed of cartilage-like tissue.
n a malignant cartilage tumor primarily found in younger adults, usually located in or near the jaw.

chondrosarcoma

a malignant tumor derived from cartilage cells or their precursors.
References in periodicals archive ?
Jux tacortical chondrosarcoma of the mandible: Report of a unique case and review of the literature.
Clear cell chondrosarcoma of bone: a report of 8 cases.
Chondrosarcoma is considered as a common primary bone sarcoma, which is ranked as the third primary bone malignancy One in five cases of bone sarcomas are due to chondrosarcoma, and half of all cases affect the pelvis (1).
It showed bony trabeculae entrapped by lobules of chondrocytes with chondroid matrix exhibiting pleomorphism, hyperchromasia, mitosis, area of myxoid change and necrosis consistent with well-differentiated chondrosarcoma.
The report provides a snapshot of the global therapeutic landscape of Chondrosarcoma
Saglik, "Secondary chondrosarcoma in cartilage bone tumors: report of 32 patients," Journal of Orthopaedic Science, vol.
Rare primary bone malignancies such as clear cell chondrosarcoma and giant cell rich osteosarcoma can also mimic GCTB but often have more destructive features, adjacent bone marrow edema, and/or a soft tissue mass component.
An increase in the thickness of the cartilaginous cap of more than 1 cm (visible on an x-ray) should raise the suspicion of chondrosarcoma (6).
The report reviews key players involved in the therapeutics development for Chondrosarcoma and enlists all their major and minor projects
OUMS-27 cell lines that have been established from chondrosarcoma cells and express chondrocytic properties are used in investigating pathophysiology of cartilage disorders due to the difficulties in obtaining chondrocytes.
Chondrosarcoma is a malignant mesenchymal tumor that produces cartilaginous matrix.
4) Chondroid bladder tumours are very rare, with only 2 reported cases of soft tissue chondroma, (1,2) and 5 of chondrosarcoma.