Identification of C11orf95-MKL2, the resulting fusion oncogene of t(11;16)(q13;p13), is useful in establishing the diagnosis of chondroid lipoma, a benign soft tissue tumor that can be mistaken for a sarcoma, especially myxoid liposarcoma or extraskeletal myxoid chondrosarcoma.
C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma.
3;p13) t(3;17)(q21;p13) t(9;17)(q22;p11-12) t(17;17)(p13;q12) Chondroid lipoma t(11;16)(q13;p12-13) Desmoid-type fibromatosis +8, +20 5q21-22 loss (a) Desmoplastic fibroblastoma t(2;11)(q31;q12) t(11;17)(q12;p11.
Chondroid lipoma is a recently described benign soft tissue tumor with a predilection for subcutaneous tissue, fascia, or skeletal muscle of the proximal extremities.
Fine-needle aspiration biopsy performed on the lesion produced the diagnosis of chondroid lipoma.
Sections from the cell block showed typical histologic features of a chondroid lipoma, including nests and cords of vacuolated lipoblast- or chondroblast-like cells admixed with mature adipocytes and embedded in a chondromyxoid matrix with an intertwined vascular network (Figure 2, A and B).
Chondroid lipoma is a peculiar benign tumor first reported by Meis and Enzinger in 1993.
Vacuolated cells similar to those seen in chondroid lipoma may occasionally also be seen in extraskeletal myxoid chondrosarcoma, but typically in much less quantity than in chondroid lipoma.
The appearance of chondroid lipoma on magnetic resonance imaging has been previously reported by Logan et al.
In this case report, we describe the cytologic features of chondroid lipoma and emphasize the usefulness of a cell block in achieving an accurate FNAB diagnosis.
Unique cytological features and chromosome aberrations in chondroid lipoma.