These results further support the hypothesis that Pb influences chondrogenesis directly and influences chondrogenic
regulation induced by BMP-2 and TGF [beta].
The periosteum was left intact, and continuous passive motion was used to stimulate chondrogenic
c-Maf Transcription factor regulates ADAMTS-12 expression in human chondrogenic
differentiation potentials of cUC-MSCs were also tested.
Mesenchymal stem cells are multipotential cells capable of proliferation and differentiation into osteogenic, chondrogenic
and adipogenic lineages both in vitro and in vivo (2, 3).
This chapter will provide investigators with some background on stem cells derived from adipose tissue and then provide details on adipose stem cell multilineage differentiation along osteogenic, adipogenic, chondrogenic
, and neurogenic lineages.
Human mesenchymal stem cells (hMSCs) can be differentiated into chondrogenic
, osteogenic, adipogenic and myogenic lineages and can be readily expanded in vitro.
Gene associations linked with rheumatic diseases: Genetic risk factors, genome-wide association studies, IL-23 and IL-1 pathways, disease susceptibility, chondrogenic
progenitor cells, regenerative therapy, -chain of the class II HLA-DR antigen, peptidylarginine deiminase-4, tyrosine phosphatase, lymphoid phosphatase, Fc receptor-like molecule-3, CD40, six genetic loci associated with autoantibody- positive RA, shortening of telomeres, gene expression profiling, early markers of response to TNF inhibition therapy, pathways for regulating immune responses and cell division, kallikrein genes, DNA methylation markers.
In addition to their myogenic property as myogenic stem cells, recent evidences indicate that some satellite cells are multipotent that can undergo adipogenic, osteogenic and chondrogenic
transdifferentiation (Mauro, 1961; Asakura et al.
8,14) SLL isolated from end-stage OA patients contains some cells that expressed typical combinations of mesenchymal progenitor cell surface markers, including CD9, and have the potency of osteogenic and chondrogenic
Brendon Noble presented studies examining the engraftment of hESC-derived chondrogenic
and osteogenic progenitor cells in rodents with cartilage or bone defects.
These results indicate that the immortalized hMSC line is a promising tool for further in vitro chondrogenic