chondrocytes


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chondrocytes

Cells that secrete the non-cellular matrix of cartilage and become trapped in minute spaces within it.
References in periodicals archive ?
Composition of Mature Adult Hyaline Articular Cartilage Extracellular matrix -- occupies 98% of cartilage volume Type II collagen fibers -- 50% dry weight Water -- 65 to 80% of total weight Proteoglycans -- 12% of total weight Chondrocytes -- occupy approximately 2% of cartilage volume Synthesize all extracellular matrix macromolecules Limited ability to repair articular cartilage defects Ability to synthesize extracellular matrix and divide decreases with age (ie, programmed senescence) Table 2.
The epiphyseal cartilage was composed of multiple discrete units of one or more chondrocytes encased in a territorial capsule and separated from each other by cleft spaces in which spindle fibroblast-like cells were easily recognizable.
3, 2014 /PRNewswire/ -- Histogenics Corporation, a regenerative medicine company focused on developing and commercializing products in the musculoskeletal space, and Intrexon Corporation(NYSE: XON), a leader in synthetic biology, today announced the formation of an Exclusive Channel Collaboration (ECC) for the generation of allogeneic chondrocyte cell therapeutics to repair damaged articular hyaline cartilage in humans.
2,10) The dense extracellular matrix in which the chondrocytes are embedded serves as a barrier to host immune surveillance limiting antigen sensitization.
The blue sky version of the stem cell approach goes like this: Stem cells are extracted from a patient, geared up to become chondrocytes, wrapped in a favorable mix of compounds and then inserted into damaged joints.
In this cartilage, the young chondrocytes, isogonics cells, territorial matrix and interterritorial matrix are distinguishable.
No production was determined by measurement of nitrite released in the culture supernatants of the chondrocytes using the Griess reaction (Green et al.
Since receptor-binding Fn peptides decrease focal contacts, disturb cytoskeletal elements such as actin and decrease Fn receptor aggregation in fibroblasts, we have proposed that Fn-fs have similar effects in chondrocytes and that these changes in receptor and cytoskeletal elements alter the location of upstream kinases near receptors which leads to altered signal transduction and emergence of inflammatory MAP kinase pathways.
We labeled chondrocytes, injected them into the defect, and followed the cells to see where they went.
Not only were the researchers able to make cells change from one type into another in the laboratory, they grew the new chondrocytes in a three-dimensional matrix, a crucial advance for success in treating humans with cartilage damage.