Giant cells are also more numerous and evenly distributed in GCT, whereas the presence of chondroblasts, cartilaginous matrix, and S100 protein or DOG1 positivity would suggest a CBT.
Characteristic features include a small, lytic lesion in the epiphysis of long bones, and the finding of chondroblasts, chondroid matrix, and assorted secondary elements on microscopy.
Thus, the idea of complementary, live biomaterials being used to give rise to osteoblasts or chondroblasts
Mesenchymal stem cells are multipotent cells that grow as adherent cells in culture and differentiate into osteoblasts, myoblasts, chondroblasts
, and adipocytes in vitro and in vivo.
They may become fibroblasts (connective tissue cells that manufacture collagen), chondroblasts
(a type of differentiated fibroblast that becomes cartilage), or osteoblasts (bone forming cells).
Also, they had ability to differentiate into osteoblasts, chondroblasts
and adipocytes in vitro (PITTENGER et al.
The development of long bones in poultry from the histogenesis process of all the wing skeleton part to the differentiation of mesenchymal cells to chondroblasts
and osteoblasts are described with a lot of
It is believed that mesenchymal cells are able to differentiated into osteoblasts and chondroblasts
, stimulated by local factors like bone morphogenetic proteins, platelet-derived growth factor, interleukin, fibroblast growth factor, insulin-like growth factor, granulocyte-colony-stimulating factors and granulocyte-macrophage colony stimulating factors (Vaccaro et al.
Areas of epithelioid differentiation, typically with more closely packed chondroblasts
with eosinophilic cytoplasm, may be mistaken for metastatic breast or lung carcinoma, the 2 lesions that most frequently metastasize to the temporal bone.
It is widely known that recombinant human morphogenetic protein type 2 (rhBMP-2), chosen for this study, is an osteoinductor protein that acts chemotactically in the differentiation of mesenchymal cells into bone synthezed cells, like osteoblasts and chondroblasts
(Ducy & Karsenty 2000; Schilephake 2002; Arosarena & Collins 2005).
Osteoclastic type of giant cells were randomly seen amid chondroblasts
arise from undifferentiated connective cells and these chondroblasts
are not aligned in columns that characterizes growth plates.