cholinergic toxidrome

cho·lin·er·gic tox·i·drome

(kō'lin-ĕr'jik tok'si-drōm)
The constellation of clinical effects (i.e., signs and symptoms) characteristic of poisoning by a cholinergic agent such as an anticholinesterase compound and caused by overstimulation and eventually fatigue and failure of cholinergically innervated target organs; typical effects involve skeletal muscle (e.g., twitching, fasciculations, weakness, paresis, paralysis), smooth muscle (e.g., miosis, bronchospasm due to overstimulation of bronchial smooth muscle, and nausea, vomiting, and diarrhea due to hyperperistalsis), exocrine glands (e.g., lacrimation, rhinorrhea, hypersalivation, bronchorrhea, diaphoresis), and neurons in the central nervous system (e.g., seizures, convulsions, central apnea).
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