cholinergic receptors

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Related to cholinergic receptors: Nicotinic receptors

cho·lin·er·gic re·cep·tors

chemical sites in effector cells or at synapses through which acetylcholine exerts its action.

cho·lin·er·gic re·cep·tors

(kō'lin-ĕr'jik rĕ-sep'tŏrz)
Chemical sites in effector cells or at synapses through which acetylcholine exerts its action.


1. parasympathomimetic; activated or transmitted by acetylcholine; said of nerve fibers that liberate acetylcholine at a synapse when a nerve impulse passes, i.e. the parasympathetic fibers.
2. an agent that resembles acetylcholine or simulates its action.

cholinergic blockade
selective inhibition of cholinergic nerve impulses at autonomic ganglionic synapses, postganglionic parasympathetic effectors, or neuromuscular junctions.
cholinergic neurotransmission
that form of neurotransmission which depends on the production of acetylcholine at synapses.
cholinergic receptors
receptor sites on effector organs or at nerve synapses that are stimulated by acetylcholine released by the nerve terminal. There are two types: muscarinic receptors, present primarily on autonomic effector cells, and nicotinic receptors, present primarily on autonomic ganglion cells and on the motor end plates of skeletal muscle.
References in periodicals archive ?
The selective muscarinic cholinergic receptor antagonists used were: pirenzepine (Ml receptor; 10 and 100 nM); methoctramine (M2 receptor; 1 and 10 AM); N-(2-chloroethyl)-4-piperidinyl diphenylacetate N-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-DAMP; M3 receptor; 10 and 100 nM); and tropicamide (M4 receptor, 1 and 10 [micro]M).
The drug's action on central muscarinic cholinergic receptors could be responsible for its effect on mood.
Also, blockade of cholinergic receptors may aggravate AD symptoms, and prevent the increase in cholinergic transmission expected from increased acetylcholine in synapses as result of cholinesterase inhibition.
The cerebellar changes in the later stages of development, however, could not have been the result of cholinesterase inhibition because the cerebellum is not innervated with cholinergic receptors like the forebrain is (Crumpton et al.
2) By contrast, clozapine's activity at M4 cholinergic receptors is agonistic.
In a recent pair of studies, we found that perinatal ETS exposure in rhesus monkeys elicits alterations in cell signaling in the developing brain akin to those identified for nicotine administration in rodents, including the up-regulation of nicotinic cholinergic receptors, a characteristic of chronic nicotineinduced neuronal stimulation (Slotkin et al.
The enhancement of the effects of ACPF by hexamethonium, promethazine and chlorpheniramine in this study could be due to allosteric activation of the cholinergic receptors through which ACPF manifests its effect on the colon.
Both phenobarbital and heroin disrupt the regional architecture of acetylcholine projections in the hippocampus, leading to parallel increases in cholinergic receptors, acetylcholine release, and expression of the presynaptic choline transporter, accompanied by behavioral and signaling defects that are not rectified by the combined presynaptic/ postsynaptic up-regulation (Steingart et al.
During brain development, acetylcholine serves as a trophic factor, regulating the differentiation of target cells containing cholinergic receptors (Hohmann and Berger-Sweeney 1998; Morley and Happe 2000; Navarro et al.
Whether neonatal exposure to PBDEs can affect cholinergic receptors in the brain is therefore of special interest and calls for further studies, because in neurodegenerative diseases, such as Alzheimer and Parkinson, there is a change in cholinergic nicotinic receptors in the cerebral cortex and hippocampus (45,46).