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cholinergic receptor

   Also found in: Encyclopedia, Wikipedia 0.01 sec.
cholinergic receptor
n.
Any of the sites in effector cells or at synapses through which acetylcholine exerts its action. Also called cholinoreceptor.

cholinergic receptor
Etymology: Gk, chole, bile, ergein, to work; L, recipere, to receive
a specialized sensory nerve ending that responds to the stimulation of acetylcholine.


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Chapter topics include: the role of prefrontal cholinergic receptors in the pathology of schizophrenia; participation of the prefrontal cortex in the processing of sexual and maternal incentives; the orbitofrontal cortex and emotional decision-making; the role of the prefrontal cortex in cognitive impairment in Parkison's disease, and noradrenergic actions in prefrontal cortex as they relate to AD/HD.
In secondary measures of outcomes, the 5-mg twice-daily dose of asenapine significantly lowered scores, compared with placebo, on subscales assessing positive symptoms, negative symptoms, and general psychopathology Asenapine binds to several serotonergic, dopaminergic, and a-adrenergic receptors, but has almost no affinity for muscarinic cholinergic receptors, and so is assumed to cause fewer significant anticholinergic side effects, compared with other antipsychotic medications.
The phosphorylated AChE cannot break down ACh and accumulation of acetylcholine in the synaptic cleft causes excess stimulation at cholinergic receptors throughout the central and peripheral nervous system.
 
 
 
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