cholinergic receptor


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Related to cholinergic receptor: adrenergic receptor, Nicotinic receptor

cholinergic receptor

Etymology: Gk, chole, bile, ergein, to work; L, recipere, to receive
a specialized sensory nerve ending that responds to the stimulation of acetylcholine.

cholinergic receptor

A site in a nerve synapse or effector cell that responds to the effect of acetylcholine.
See also: receptor
References in periodicals archive ?
Indeed, both chlorpyrifos and chlorpyrifos oxon are capable of direct actions on muscarinic and nicotinic cholinergic receptors, influencing second messenger production (26-28) and ion fluxes (29,30); hence, even some of the cholinotypic actions on developing systems may be mechanistically unrelated to inhibition of cholinesterase activity.
Zarate has pioneered a series of rapidly acting antidepressants by the intravenous route, including the glutamate-active compound ketamine and the blocker of cholinergic receptors scopolamine.
QUEBEC CITY, May 20, 2013 /PRNewswire/ -- Asmacure Ltee, a clinical-stage biopharmaceutical company focused on the development of novel, proprietary compounds that target cholinergic receptors for the treatment of pulmonary diseases, today announced presentations of four studies of ASM-024, Asmacure's lead compound in development for asthma and chronic obstructive pulmonary disease (COPD).
SANTIAGO, CHILE -- Treatment with scopolamine hydrobromide blocks muscarinic cholinergic receptors and produces a rapid, robust antidepressant response in depressed patients with unipolar or bipolar depression, Maura L.
QUEBEC CITY, May 16, 2013 /PRNewswire/ -- Asmacure Ltee, a clinical-stage biopharmaceutical company focused on the development of novel, proprietary compounds that target cholinergic receptors for the treatment of pulmonary diseases, today announced that the company will present four posters at the 2013 American Thoracic Society (ATS) International Conference, taking place May 17-22 in Philadelphia.
QUEBEC CITY, Canada, April 15, 2013 /PRNewswire/ -- Asmacure Ltee, a clinical-stage biopharmaceutical company focused on the development of novel, proprietary compounds that target cholinergic receptors for the treatment of pulmonary diseases, announced the start of a phase 1/2 clinical trial of its lead compound, ASM-024, in a dry powder for inhalation (DPI) formulation.
In a recent pair of studies, we found that perinatal ETS exposure in rhesus monkeys elicits alterations in cell signaling in the developing brain akin to those identified for nicotine administration in rodents, including the up-regulation of nicotinic cholinergic receptors, a characteristic of chronic nicotineinduced neuronal stimulation (Slotkin et al.
The enhancement of the effects of ACPF by hexamethonium, promethazine and chlorpheniramine in this study could be due to allosteric activation of the cholinergic receptors through which ACPF manifests its effect on the colon.
SIBIA has an extensive portfolio of proprietary drug discovery targets encompassing gene families encoding voltage and ligand-gated ion channels including voltage-gated calcium channels (VGCCs), nicotinic cholinergic receptors (nAChRs) and excitatory amino acid receptors (EAARs).
Both phenobarbital and heroin disrupt the regional architecture of acetylcholine projections in the hippocampus, leading to parallel increases in cholinergic receptors, acetylcholine release, and expression of the presynaptic choline transporter, accompanied by behavioral and signaling defects that are not rectified by the combined presynaptic/ postsynaptic up-regulation (Steingart et al.
AF102B is a selective M(1) agonist acting at post-synaptic, cholinergic receptors.