cholinergic blockade

blockade /block·ade/ (blok-ād´)

1. the blocking of the effect of a hormone or neurotransmitter at a cell-surface receptor by a pharmacologic antagonist bound to the receptor.

2. in histochemistry, a chemical reaction that modifies certain chemical groups and blocks a specific staining method.

3. regional anesthesia.

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adrenergic blockade  selective inhibition of the response to sympathetic impulses transmitted by epinephrine or norepinephrine at alpha or beta receptor sites of an effector organ or postganglionic adrenergic neuron.

cholinergic blockade  selective inhibition of cholinergic nerve impulses at autonomic ganglionic synapses, postganglionic parasympathetic effectors, or the neuromuscular junction.

ganglionic blockade  inhibition by drugs of nerve impulse transmission at autonomic ganglionic synapses.

narcotic blockade  inhibition of the euphoric effects of narcotic drugs by the use of other drugs, such as methadone, in the treatment of addiction.

neuromuscular blockade  a failure in neuromuscular transmission that can be induced pharmacologically or may result from pathological disturbances at the myoneural junction.

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cholinergic blockade

n.

1. Inhibition by a drug of nerve impulse transmission at autonomic ganglionic synapses, postganglionic parasympathetic effector cells, and myoneural junctions.

2. Inhibition of a cholinergic agent.

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blockade

1. in pharmacology, the blocking of the effect of a neurotransmitter or hormone by a drug.

2. in histochemistry, a chemical reaction that modifies certain chemical groups and blocks a specific staining method.

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adrenergic blockade

see adrenergic blockade.

cholinergic blockade

see cholinergic blockade.

narcotic blockade

inhibition of the euphoric effects of narcotic drugs by the use of other drugs, such as methadone, in the treatment of addiction.

sympathetic blockade

block of nerve impulse transmission between a preganglionic sympathetic fiber and the ganglion cell.

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cholinergic

1. parasympathomimetic; activated or transmitted by acetylcholine; said of nerve fibers that liberate acetylcholine at a synapse when a nerve impulse passes, i.e. the parasympathetic fibers.

2. an agent that resembles acetylcholine or simulates its action.

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cholinergic blockade

selective inhibition of cholinergic nerve impulses at autonomic ganglionic synapses, postganglionic parasympathetic effectors, or neuromuscular junctions.

cholinergic neurotransmission

that form of neurotransmission which depends on the production of acetylcholine at synapses.

cholinergic receptors

receptor sites on effector organs or at nerve synapses that are stimulated by acetylcholine released by the nerve terminal. There are two types: muscarinic receptors, present primarily on autonomic effector cells, and nicotinic receptors, present primarily on autonomic ganglion cells and on the motor end plates of skeletal muscle.