choline acetyltransferase


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Related to choline acetyltransferase: choline acetylase

choline

 [ko´lēn]
an amine that occurs in phosphatidylcholine and acetylcholine, and is an important methyl donor in intermediary metabolism. Choline is a lipotropic agent, a substance that decreases liver fat content by increasing phospholipid turnover. It was formerly considered to be a B vitamin and is now classified as a pseudovitamin, although it is still sometimes classified as part of the vitamin B complex. Vitamin B12 and folacin are involved in the synthesis of choline.
choline acetylase (choline acetyltransferase) an enzyme that brings about the synthesis of acetylcholine.
choline magnesium trisalicylate see under trisalicylate.
choline salicylate see salicylate.

cho·line a·ce·tyl·trans·fer·ase

[MIM*118490]
an enzyme catalyzing the condensation of choline and acetyl-coenzyme A, forming O-acetylcholine and coenzyme A.
Synonym(s): choline acetylase

choline acetyltransferase

/cho·line ac·e·tyl·trans·fer·ase/ (ko´lēn as″ĕ-tēl-trans´fer-ās) an enzyme catalyzing the synthesis of acetylcholine; it is a marker for cholinergic neurons.

choline acetyltransferase

An enzyme encoded by CHAT on chromosome 10q11.2 that binds acetylCoA to choline, controlling acetylcholine production at the synapses of autonomic nervous system, muscle and the sympathetic nervous system.

Molecular pathology
Polymorphisms of CHAT have been associated with choline acetyltransferase depletion in Alzheimer’s disease and cognitive impairment. CHAT mutations are associated with congenital myasthenic syndrome with episodic apnoea.

choline acetyltransferase

Choline acetylase An enzyme which controls acetylcholine production in synapses of the autonomic nervous system, muscle, and SNS, which may be depleted in Alzheimer's disease

cho·line a·ce·tyl·trans·fer·ase

(kō'lēn ăs'e-til-trans'fĕr-ās)
An enzyme catalyzing the condensation of choline and acetyl-coenzyme A, forming O-acetylcholine and coenzyme A.
References in periodicals archive ?
Influence of a combination of two tetrachlorobiphenyl congeners (PCB 47; PCB 77) on thyroid status, choline acetyltransferase (ChAT) activity, and short- and long-term memory in 30-day-old Sprague-Dawley rats.
Prevention of age-related memory deficit in transgenic mice by human choline acetyltransferase.
Yabe T, Iizuka S, Komatsu Y, Yamada H (1997) Enhancements of choline acetyltransferase activity and nerve growth factor secretion by Polygalae radix-extract containing active ingredients in Kami-untan-to.
Gnahn H, Hefti F, Heumann R, Schwab ME, Thoenen H (1983) NGF-mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: evidence for a physiological role of NGF in the brain?
Fonnum F (1975) A rapid radiochemical method for the detemination of choline acetyltransferase.