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choline acetyltransferase

   Also found in: Acronyms, Wikipedia 0.04 sec.
choline acetyltransferase /cho·line ac·e·tyl·trans·fer·ase/ (ko´len as?e-tel-trans´fer-as) an enzyme catalyzing the synthesis of acetylcholine; it is a marker for cholinergic neurons.
choline acetyltransferase
n.
An enzyme, present at the presynaptic ends of axons, that catalyzes the transfer of the acetyl group of acetyl CoA to choline, forming acetylcholine.
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At the same time, CPF increased the expression of tyrosine hydroxylase (TH), the enzymatic marker for the catecholamine phenotype, without affecting choline acetyltransferase (CHAT), the corresponding marker for the cholinergic phenotype.
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And the activity of their choline acetyltransferase, an important brain enzyme, was subtly but significantly impaired.
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Similar correlations were noted between enhanced choline acetyltransferase immunoreactivity and decreased calcineurin," Dr.
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