cholesteryl

cholesteryl

/cho·les·ter·yl/ (kah-les´ter-il″) the radical of cholesterol, formed by removal of the hydroxyl group.
References in periodicals archive ?
Cholesteryl ester transfer protein inhibitor (JTT-705) and the development of atherosclerosis in rabbits with severe hypercholesterolaemia.
The new nonstatin drug classes that he expects to dominate discussions of lipid-lowering drugs in the next few years are cholesteryl ester transfer protein (CETP) inhibitors, peroxisome proliferator-activated receptor (PPAR) agonists, and acyl coenzyme A: cholesterol acyltransferase (ACAT) inhibitors.
LAL D was historically called Cholesteryl Ester Storage Disease in children and adults, and Wolman disease in infants.
It will not be until the completion of combination trials using statin plus niacin analogs and statin plus cholesteryl ester transfer protein inhibitors vs statin alone by 2012-2014 that we will have a better idea as to how to treat 2 other independent CHD risk factors: low HDL cholesterol and increased lipoprotein or Lp(a).
Prior to REVEAL, the DEFINE (Determining the Efficacy and Tolerability of Cholesteryl Ester Transfer Protein[CETP] Inhibition with Anacetrapib) Phase III study demonstrated the ability of anacetrapib to dramatically shift the LDL/HDL ratio, a critical biomarker-based milestone that must be met in the route to approval in the dyslipidemia market.
Those cholesterol-reducing drugs that followed statins were cholesteryl ester transporter protein (CETP) inhibitors, Niemann-Pick Cl-like 1 (NPC1L1) inhibitors, microsomal triglyceride transfer protein (MTTP) inhibitors, and acyl-CoA cholesterol acyltransferase (ACAT) inhibitors.
LAL Deficiency presenting in children and adults, historically called Cholesteryl Ester Storage Disease, is an underappreciated cause of cirrhosis and accelerated atherosclerosis.
During this process, these lipoproteins lose triglyceride and pick up cholesteryl ester and apolipoprotein E (apoE) from other lipoproteins through the action of cholesteryl ester transfer protein.
Poster 1339 entitled "Enzyme Replacement with Recombinant Human Lysosomal Acid Lipase (rhLAL) in Patients with Cholesteryl Ester Storage Disease, the Late Onset Form of LAL Deficiency, Produces Sustained Decreases in Transaminases and Reduction in Liver Fat Content" can be viewed during the poster session on Monday, November 12, 2012 at 8:00 a.
Experience with torcetrapib, an inhibitor of the cholesteryl ester transfer protein (CETP), has raised the most profound questioning regarding the value of increasing HDL-C concentrations to decrease cardiovascular risk.
Cholesteryl ester transfer protein inhibition, highdensity lipoprotein metabolism and heart disease risk reduction.
During a poster session at the NSGC meeting, investigators presented their analysis of 135 cases of late onset LAL Deficiency (or Cholesteryl Ester Storage Disease, CESD) found in the published scientific literature for whom clinical information, liver pathology, and serum lipid levels were reported.

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