The biosynthesis of cholesterol.
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In a diabetic dog model, the MVA excretion was increased together with both HMG-CoA reductase activity and cholesterologenesis in the intestine and liver (12-13).
Intestinal and hepatic cholesterologenesis in hypercholesterolemic dyslipidemia of experimental diabetes in dogs.
Studies of a diabetic rat model revealed that the cholesterologenesis in the gut was increased along with increases of plasma cholesterol and triglyceride concentrations (14-18); however, the urinary MVA in a diabetic model has not yet been reported.
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