We hypothesize that an active cholesterol metabolism
isessential for prostate cancer-initiating cell function, and that the use of cholesterol synthesis inhibitors might target this subpopulation of aggressive cancer cells.
About Foundation of the National Lipid Association (FNLA) The Foundation of the National Lipid Association supports and conducts educational programs, research programs, and vital community outreach programs for both patients and clinicians in an effort to reduce cardiovascular events and deaths related to disorders of dyslipidemia and cholesterol metabolism
In addition to being reservoirs for excess cholesterol, bile acids are also potent signaling molecules that regulate cholesterol metabolism
via the action of the farnesoid X receptor (FXR).
These new drugs have different mechanism of actions: inhibiting or activating genes / proteins in cholesterol metabolism
One of genes discovered to be associated with IOP was ABCA1, which plays a role in maintaining cell membranes by regulating lipid and cholesterol metabolism
Mechanism for microbiota influence of cholesterol metabolism
When researchers examined cells from the animals' livers -- the main site of fat synthesis and breakdown -- they noticed marked differences in the expression of several genes that regulate cholesterol metabolism
Selenium could also influence cholesterol metabolism
, since the peroxidase glutathione enzyme (GPX) is selenium dependent and the reductase glutathione enzyme acts on the GSH/GSSG ratio.
Recent studies led by our centre have provided important new scientific insights, implicating dysfunction of the immune system and cholesterol metabolism
in vulnerability to Alzheimer's Disease and abnormalities in the way that brain cells communicate in schizophrenia.
They team examined the cardiac effects of a carnitine-enhanced diet in normal mice compared to mice with suppressed levels of gut microbes, and discovered that TMAO altered cholesterol metabolism
at multiple levels, explaining how it enhanced the problem.
12 ( ANI ): Scientists have linked the eating disorder anorexia to variants in a gene coding for an enzyme that regulates cholesterol metabolism
Other articles examine sarcopenia and smoking, the link between altered cholesterol metabolism
and Alzheimer's disease, the properties of rottlerin and curcumin, the effects of plant polyphenols on the skin, the relevance of flavinoids for metabolic syndrome, dietary polyphenols and cancer prevention, cigarette smoke and ozone effects on murine inflammatory responses, the role of dietary nutrients in age-related changes in gene expression, the role of oxidative stress in Rett syndrome, and cutaneous wound repair.