d) 400x, a multinucleated giant cell with a cholesterol cleft
(arrow); an early manifestation in the development of cholesterol granulomas.
Rupture may result in fibrosis, granulation tissue, hemorrhage, and cholesterol cleft
formation or cholesterol granuloma.
These sections were studied for the presence of fibrosis, giant cells, granulomas, cholesterol clefts
, acute inflammation, and association with adenocarcinomas.
Histopathology revealed that granulomatous tissue consisted of cholesterol clefts
, lymphoplasmacellular infiltrates, marked hemosiderin deposits, and multinucleated foreign body giant cells around cholesterol clefts
[Figure 1]e-[Figure 1]g.
The lumen contained eosinophilic homogenous hyalinized material with many cholesterol clefts
and red blood cells.
and foreign body type giant cell reaction was also noted.
Granulations, keratin flakes in crypts, cholesterol clefts
and tonsillar cysts comprise less than 5% of histopathological findings and therefore should not be considered pathognomic of chronic tonsillitis.
formed by cholesterol crystals were diffusely present within the fibrinoid material (Fig.
and multinucleated giant cells may be seen, along with occasional calcifications.
Elements of bone, cartilage, cholesterol clefts
and inflammatory cells were identified in a few places.
Numerous cholesterol clefts
with associated multinucleated foreign body giant cells were also seen (Fig 5).
Intravascular cholesterol clefts
as an incidental finding: cholesterol embolism or nots Am J Dermatopathol 2003; 25: 497-9.