intrahepatic cholestasis of pregnancy

(redirected from cholestatic hepatosis icterus gravidarum)
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intrahepatic cholestasis of pregnancy

intrahepatic cholestasis with centrilobular bile staining without inflammatory cells or proliferation of mesenchymal cells; clinically characterized by pruritus and icterus; of unknown cause but associated with high estrogen levels.

intrahepatic cholestasis of pregnancy

a type of intrahepatic cholestasis sometimes seen during the third trimester of pregnancy, characterized by severe itching, hepatomegaly, and sometimes jaundice. It clears up after delivery. The cause is unknown, but because it occurs far more in certain ethnic groups than in others, there may be a genetic link.

in·tra·he·pat·ic cho·le·sta·sis of preg·nan·cy

(in'tră-hĕ-pat'ik kō'lē-stā'sis preg'năn-sē)
Intrahepatic cholestasis with centrilobular bile staining without inflammatory cells or proliferation of mesenchymal cells; clinically characterized by pruritus and/or icterus; of unknown cause but associated with high estrogen levels.
Synonym(s): cholestasis of pregnancy, recurrent jaundice of pregnancy.

intrahepatic cholestasis of pregnancy

Abbreviation: ICP
A complication of approx. 1% of pregnancies in which elevated levels of pregnancy hormones cause obstruction to bile flow within the liver. Levels of bilirubin rise in the maternal circulation during the second and third trimesters of pregnancy, causing itching, bile staining of urine, and a lighter stool color than normal. ICP increases the risk of preterm delivery of the fetus and of bleeding disorders and loss of life of the fetus. Synonym: obstetric cholestasis
See also: cholestasis