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Tending to diminish or stop the flow of bile.


Tending to diminish or stop the flow of bile.


, cholestasia (ko?le-sta'sis) (ko?le-sta'zh(e-)a) [ chole- + stasis]
Arrest of the flow of bile. This may be due to intrahepatic causes, obstruction of the bile duct by gallstones, or any process that blocks the bile duct (e.g., cancer). cholestatic (ko?le-stat'ik), adjective

intrahepatic cholestasis of pregnancy

Abbreviation: ICP
A complication of approx. 1% of pregnancies in which elevated levels of pregnancy hormones cause obstruction to bile flow within the liver. Levels of bilirubin rise in the maternal circulation during the second and third trimesters of pregnancy, causing itching, bile staining of urine, and a lighter stool color than normal. ICP increases the risk of preterm delivery of the fetus and of bleeding disorders and loss of life of the fetus. Synonym: obstetric cholestasis

obstetric cholestasis

Intrahepatic cholestasis of pregnancy.

progressive familial intrahepatic cholestasis

Byler disease.


Tending to diminish or stop the flow of bile.
References in periodicals archive ?
MDR3 (ABCB4) Defects: A Paradigm for the Genetics of Adult Cholestatic Syndromes.
Oxidative DNA damage emerged due to the cholestatic damage was measured by 8-OHdG identification with the ELISA method.
These enzymes are not greatly elevated in cholestatic diseases except during the acute phase of biliary obstruction.
Guideline for the evaluation of cholestatic jaundice in infants: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition.
Autoantibodies against tumor-associated antigens (TAA) represent promising candidates for NIBMs in liver malignancies, such as cholangiocarcinoma [9], and early states of malignancies, like early chronic cholestatic liver injury.
However, EBV hepatitis and cholestatic jaundice have been recently described in patients without the clinical manifestations of EBV-associated infectious mononucleosis.
Despite this knowledge, the role of hepatic cholesterol accumulation in cholestatic liver disease has not been thoroughly examined.
5 years after LT course and a diagnosis of late onset biliary anastomotic stricture, which was recognized during the work-up of new onset cholestatic hepatitis 6 months prior to this admission.
As for liver injury type, 8 cases were hepatocellular, 2 were cholestatic, and 1 was of mixed pattern.
The information provided in the manuscript does not substantiate a causal relationship between the consumption of Herbalife's Formula 1 shake and either of the two different presentations (one cholestatic and one hepatocellular liver injury) which are being attributed to DILI.
2,3] These changes are particularly prominent in children with severe cholestatic liver disease such as biliary atresia and the severe intrahepatic causes of CLD.
A cholestatic damage pattern is characterized by an increase in ALP greater than 3 times the ULN and/or an ALT/ALP ratio less than 2.