intrahepatic cholestasis of pregnancy

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intrahepatic cholestasis of pregnancy

intrahepatic cholestasis with centrilobular bile staining without inflammatory cells or proliferation of mesenchymal cells; clinically characterized by pruritus and icterus; of unknown cause but associated with high estrogen levels.

intrahepatic cholestasis of pregnancy

a type of intrahepatic cholestasis sometimes seen during the third trimester of pregnancy, characterized by severe itching, hepatomegaly, and sometimes jaundice. It clears up after delivery. The cause is unknown, but because it occurs far more in certain ethnic groups than in others, there may be a genetic link.

in·tra·he·pat·ic cho·le·sta·sis of preg·nan·cy

(in'tră-hĕ-pat'ik kō'lē-stā'sis preg'năn-sē)
Intrahepatic cholestasis with centrilobular bile staining without inflammatory cells or proliferation of mesenchymal cells; clinically characterized by pruritus and/or icterus; of unknown cause but associated with high estrogen levels.
Synonym(s): cholestasis of pregnancy, recurrent jaundice of pregnancy.

intrahepatic cholestasis of pregnancy

Abbreviation: ICP
A complication of approx. 1% of pregnancies in which elevated levels of pregnancy hormones cause obstruction to bile flow within the liver. Levels of bilirubin rise in the maternal circulation during the second and third trimesters of pregnancy, causing itching, bile staining of urine, and a lighter stool color than normal. ICP increases the risk of preterm delivery of the fetus and of bleeding disorders and loss of life of the fetus. Synonym: obstetric cholestasis
See also: cholestasis
References in periodicals archive ?
Jude Children's Research Hospital scientists advance understanding of intrahepatic cholestasis of pregnancy, a liver disorder that leaves infants born to affected mothers at risk for severe respiratory distress
In some predisposed women, the metabolic changes are adequately severe to lead to development of gestational disorders of pregnancy including gestational diabetes mellitus (GDM) and intrahepatic cholestasis of pregnancy (ICP).
The intense itchiness had been a sign of intrahepatic cholestasis of pregnancy (ICP), aSHOW YOUR SUPPORT WITH A PINK FRIDAY BREAST Cancer Care is encouraging people to take part in its Pink Friday fundraising campaign during Breast Cancer Awareness Month.
Some doctors wrote the reason for early delivery as "intrahepatic cholestasis of pregnancy," which is an appropriate indication, but the medical coders told Dr.
Obstetric cholestasis, also known as intrahepatic cholestasis of pregnancy, is a relatively uncommon liver disorder that classically presents in the third trimester (Royal College of Obstetricians and Gynecologists [RCOG], 2006).
Pruritus was reduced more effectively in patients with intrahepatic cholestasis of pregnancy after treatment with ursodeoxycholic acid, according to a randomized study of 84 symptomatic patients in Lithuania.
As one example, an induction of labor at 37 weeks for cholestasis of pregnancy would be considered an "elective early delivery" by the Leapfrog Group's current reporting methods.
Cholestyramine has been used as a treatment for intrahepatic cholestasis of pregnancy and as an antidote for some types of diarrhea, cholordecone pesticide poisoning, and digitalis toxicity.
Cholestasis of pregnancy does not include primary skin lesions, but it can have serious effects for both mother and fetus.
VIENNA -- An elevated serum bile acid level is a highly reliable indicator of intrahepatic cholestasis of pregnancy in a woman who presents with itching and excoriated skin lesions late in gestation, Christina M.
SAN FRANCISCO -- Check serum bile acid levels to determine if severe itching during pregnancy is the result of intrahepatic cholestasis of pregnancy, advises a dermatologic pathologist.