It appears to increase choleresis
, with protection of cholangiocytes and hepatocytes.
ALE considerably increases choleresis in healthy volunteers (Kirchhoff et al.
Increase in choleresis by means of artichoke extract.
UDCA is a hydrophilic, non-toxic bile acid that induces a choleresis
Choleresis was two- to three-fold higher than that of cynarin.
Moreover, a randomised placebo-controlled double-blind cross-over study revealed an increase in choleresis up to 51.
High-dosed artichoke leaf extract (ALE) caused a considerable increase in choleresis
, most likely due to an increased bile production into the duodenum of healthy volunteers (Kirchhoff et al.
It seems that [alpha]-asarone induced clearance of cholesterol from the bloodstream and that the excess of hepatic cholesterol provided by LDL-cholesterol is diverted to bile sterol secretion via a bile choleresis
The increase in choleresis
associated with an increased formation of bile compounds has been shown in animal experiments (Frohlich and Mayr, 1973; Khadzhai and Kuznetsova, 1971; Lietti, 1977; Okamoto, 1940; Preziosi, 1962; Preziosi and Loscalco, 1956; Preziosi et al.
Kirchhoff R, Beckers CH, Kirchhoff G, et al (1994) Increase in choleresis
by means of artichoke extract.