cholangiocarcinoma


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cholangiocarcinoma

 [ko-lan″je-o-kahr″sĭ-no´mah]
1. an adenocarcinoma arising from the epithelium of the intrahepatic bile ducts, composed of eosinophilic cuboidal or columnar epithelial cells, with abundant fibrous stroma; mucus may be secreted but not bile.

chol·an·gi·o·car·ci·no·ma

(kō-lan'jē-ō-kar'si-nō'mă),
An adenocarcinoma, primarily in intrahepatic bile ducts, composed of ducts lined by cuboidal or columnar cells that do not contain bile, with abundant fibrous stroma; cirrhosis is usually absent.

cholangiocarcinoma

/cho·lan·gi·o·car·ci·no·ma/ (ko-lan″je-o-kahr″sĭ-no´mah)
1. an adenocarcinoma arising from the epithelium of the intrahepatic bile ducts and composed of epithelial cells in tubules or acini with fibrous stroma.

cholangiocarcinoma

[kōlan′jē·ōkär′sinō′mə]
a cancer of the biliary epithelium. Risk factors include ulcerative colitis and infestation of liver flukes. Diagnosis is based on histological evaluation, and the prognosis is poor.

cholangiocarcinoma

A rare (5/105/year) cancer of intrahepatic bile ducts, seen > age 60.
 
Aetiology
Anabolic steroids, liver flukes (Clonorchis sinensis), ulcerative colitis, cholecystitis, cholelithiasis, primary sclerosing cholangitis, malformations, cirrhosis.

Clinical findings
Obstruction, jaundice, abdominal pain, weight loss.

Location
Hilar, 50–60%; intrahepatic, 10%; extrahepatic 20–30%.

Prognosis
53% 1-year survival; 4% 5-year survival.

cholangiocarcinoma

Bile duct cancer, cancer of bile ducts A rare–5/100,000/yr cancer of intrahepatic bile ducts seen > age 60 Etiology Anabolic steroids, Thorotrast,.Clonorchis sinensis, possibly ulcerative cholitis, cholecystitis; not associated with alcohol abuse Clinical Jaundice—71%, abdominal pain-49%, weight loss—44% Prognosis 53% 1-yr survival, 9% 3-yr, 4% 5-yr. Cf Hepatocellular carcinoma.

chol·an·gi·o·car·ci·no·ma

(kō-lan'jē-ō-kahr-si-nō'mă)
An adenocarcinoma, primarily in intrahepatic bile ducts, composed of ducts lined by cuboidal or columnar cells that do not contain bile, with abundant fibrous stroma.

cholangiocarcinoma

Cancer of the bile ducts.

cholangiocarcinoma

see cholangiocellular carcinoma.
References in periodicals archive ?
Cell lines used in the study included human cholangiocarcinoma TFK-1, human biliary epithelial carcinoma HuCCT-1, and human cholangiocarcinoma RBE.
In this study, we aimed to investigate the efficacy of salinomycin in the treatment of cholangiocarcinoma, and to determine if it could reverse chemoresistance to doxorubicin.
3) Immunomarkers may also be used to help distinguish intrahepatic cholangiocarcinoma from hepatic metastasis of pancreatic ductal adenocarcinoma, distinguish pancreatic acinar cell carcinoma from other solid pancreatic neoplasms, and subclassify ampullary adenocarcinoma.
A) Neoplastic epithelial cells arranged in irregular tubules, acini, and cords that infiltrate the hepatic parenchyma and are characteristic of a cholangiocarcinoma.
Conclusion: Our findings provide new evidence that GLE suppress cholangiocarcinoma migration in vitro through inhibition of TGF-[beta]1-induced EMT.
Cholangiocarcinoma (CC) is the second most common primary malignancy of the liver after hepatocellular carcinoma (HCC).
angry ever the " The money raised by Elaine and other family members has been donated to the Cholangiocarcinoma Foundation in the Us to help fund research they hope will one day eradicate this strain of cancer.
Gores, "The utility of CA 19-9 in the diagnoses of cholangiocarcinoma in patients without primary sclerosing cholangitis," The American Journal of Gastroenterology, vol.
In some case there is involvement of GB fossa as well as hilar region by mass lesion, in such cases it becomes difficult to define whether CA GB extending to hilar region or it is Primary Hilar Cholangiocarcinoma, so this becomes limiting factor for MRCP.
Complex anatomical areas are characterized by multiple origin tumors, all of which with the same histological patter: adenocarcinomas--ampulloma, cholangiocarcinoma, gallbladder cancer and pancreatic or rarely duodenal cancer.
The tumor types include the following forms of cancer; Breast adenocarcinoma, Colorectal, Gastric & Gastroesophageal, Pancreatic, Cholangiocarcinoma, Lung (NSCLC), Head & Neck (SCC), Melanoma and Ovarian adenocarcinoma.