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Correction of Hemoglobin and Outcomes in Renal Insufficiency. A trial that studied the use of epoetin alfa treatment to achieve two different target haemoglobin levels in patients with chronic kidney disease
Conclusion The use of a target haemoglobin level of 13.5 g/dl (as compared with 11.3 g/dl) was associated with increased risk and no incremental improvement in the quality of life; the reason is uncertain; theories include some nebulous toxicity from the recombinant epoietin, iron toxicity, and altered blood viscosity, increased platelet activity