chlorpropamide


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chlorpropamide

 [klor-pro´pah-mīd]
an oral sulfonylureahypoglycemic agent useful in treatment of type 2 diabetes mellitus in the adult whose condition is stabilized; it is contraindicated in patients with impairment of renal, thyroid, or hepatic function. Dosage is individually adjusted.

chlorpropamide

/chlor·pro·pa·mide/ (-pro´pah-mīd) a sulfonylurea used as a hypoglycemic in the treatment of type 2 diabetes mellitus.

chlorpropamide

(klôr-prō′pə-mīd′)
n.
A long-acting sulfonylurea drug, C10H13ClN2O3S, used to treat type 2 diabetes.

chlorproPAMIDE

[-prō′pəmīd]
an oral antidiabetic.
indication It is prescribed in the treatment of non-insulin-dependent diabetes mellitus.
contraindications Liver or kidney dysfunction or known hypersensitivity to this drug prohibits its use.
adverse effects Among the most serious adverse reactions are hematologic derangements and jaundice. Hypoglycemia, GI distress, and rashes are common adverse effects.

chlorpropamide

Endocrinology An oral sulfonylurea hypoglycemic, structurally related to tolbutamide, which ↑ release of insulin from beta islet cells in Pts with type 2 DM

chlorpropamide

long-acting sulphonylurea (oral hypoglycaemic) agent; used to treat younger non-obese patients with type 2 diabetes; also used to treat diabetes insipidus (sensitizes renal tubules to antidiuretic hormone)

chlorpropamide,

n brand names: Apo-Chlorpromide, Diabinese;
drug class: antidiabetic, first generation sulfonylurea;
action: causes functioning beta cells in pancreas to release insulin, leading to drop in blood glucose levels;
uses: stable type 2 diabetes mellitus.

chlorpropamide

a first generation sulfonylurea derivative, used as an oral hypoglycemic drug in the treatment of diabetes mellitus.
References in periodicals archive ?
c) Includes ami-doarone, carbamazepine, chlorpropamide, carbidopa/levodopa, heparin, interferon, lithium, phenytoin, phenobarbital, or sulfasalazine.
The sulfonylurea class medications used were glipizide (45%), glyburide (33%), glimepiride (20%), tolazamide (1%), and chlorpropamide (0.
The lag-time after application of transdermal form varies from 3-4 hours for propranolol to 10-12 hours for chlorpropamide.
Generic name Brand name acetohexamide Dymelor chlorpropamide Diabinese glimepiride Amaryl glipizide Glucotrol, Glucotrol XL glyburide DiaBeta, Glynase, PresTab, Micronase tolazamide Tolinase tolbutamide Orinase
23] Patients with partial neurogenic DI may also benefit from the oral hypoglycemic agent, chlorpropamide, which stimulates the release of ADH from the pituitary gland and augments renal tubule response to ADH.
For example, the commonly prescribed diabetes medication chlorpropamide and the antibiotics cefotetan and metronidazole can induce disulfiram-like reactions, even after ingestion of only small alcohol amounts.
These include blood-sugar-lowering medications for diabetes, such as chlorpropamide, glipizide, glybutide, and tolbutamide.
Oral Hypoglycemic Agents: In pharmacokinetic studies of MEVACOR in hypercholesterolemic non-insulin dependent diabetic patients, there was no drug interaction with glipizide or with chlorpropamide (see CLINICAL PHARMACOLOGY, Clinical Studies).
Gluburide has short half-life but prolonged biological effect due to the formation of active metabolites which are also metabolized in liver similar to chlorpropamide.
No significant difference in microvascular risk reduction was observed among the chlorpropamide, glibenclamide, and glipizide treatment modalities.
These include chlorpropamide and tolbutamide, which are not thought to cause congenital defects, but more studies are needed before they are completely excluded as possible teratogens.