chloroquine


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Related to chloroquine: hydroxychloroquine, chloroquine phosphate

chloroquine

 [klor´o-kwin]
1. an antimalarial and antiprotozoal agent, also used as a lupus erythematosus suppressant.
2. an antiamebic and antiinflammatory agent used in treatment of malaria, giardiasis, non-intestinal amebiasis, lupus erythematosus, and rheumatoid arthritis; used as the base, hydrochloride salt, or phosphate salt.

chlor·o·quine

(klōr'ō-kwīn),
An antimalarial agent used for the treatment and suppression of Plasmodium vivax, P. malariae, and P. falciparum; available in phosphate and sulfate forms. It does not produce a radical cure because it has no effect on the exoerythrocytic stages; chloroquine-resistant strains of P. falciparum have developed in Southeast Asia, Africa, and South America. It is also used for hepatic amebiasis and for certain skin diseases, for example, lupus erythematosus and lichen planus.

chloroquine

/chlo·ro·quine/ (klor´o-kwin) an antiamebic and anti-inflammatory used in the treatment of malaria, giardiasis, extraintestinal amebiasis, lupus erythematosus, and rheumatoid arthritis; used also as the hydrochloride and phosphate salts.

chloroquine

(klôr′ə-kwīn′, -kwēn′)
n.
A drug, C18H26ClN3, used usually in its phosphate form to prevent and treat malaria and to treat amebiasis that has spread outside the intestines.

chloroquine

[klôr′əkwīn′]
an antimalarial.
indications It is prescribed in the treatment of malaria, extraintestinal amebiasis, rheumatoid arthritis, discoid lupus erythematosus, scleroderma, pemphigus, and photoallergic reactions.
contraindications Retinal or visual field changes, porphyria, or known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse reactions are GI disturbances, headache, visual disturbances resulting from retinal damage, and pruritus. It can turn the skin blue/black and/or the urine brown/black, bleach the hair, and cause photosensitivity.

chlor·o·quine

(klōr'ō-kwīn)
An antimalarial agent used for the treatment and suppression ofPlasmodium vivax, P. malariae, and P. falciparum; available in phosphate and sulfate forms. It is also used for hepatic amebiasis and for certain skin diseases, e.g., lupus erythematosus and lichen planus.

chloroquine

A drug used in the treatment of MALARIA, RHEUMATOID ARTHRITIS and lupus erythematosus. In 1993 the clinical effectiveness of chloroquine in Malawi was less than 50 percent and it was replaced by sulfadoxine and pyrimethamine. But ten years late the efficiency had risen again to 99 percent. The drug is on the WHO official list. Brand names are Avoclor and Nivaquine.

Chloroquine

An antimalarial drug that was first used in the 1940s, until the first evidence of quinine resistance appeared in the 1960s. It is now ineffective against falciparum malaria almost everywhere. However, because it is inexpensive, it is still the antimalarial drug most widely used in Africa. Native individuals with partial immunity may have better results with chloroquine than a traveler with no previous exposure.
Mentioned in: Malaria

chloroquine

antimalarial drug used to treat recalcitrant rheumatoid arthritis and mild systemic lupus erythematosus (note: contraindicated in psoriatic arthropathy)

chlor·o·quine

(klōr'ō-kwīn)
An antimalarial agent used for the treatment and suppression of Plasmodium vivax, P. malariae, and P. falciparum; also used for hepatic amebiasis and some skin diseases.

chloroquine

an antiprotozoal agent, used in the treatment of avian malaria, anaplasmosis and theileriosis in cattle and amebiasis in non-human primates.

chloroquine poisoning
the drug has an affinity for melanin and ocular tissues with melanin; causes a drug-induced retinopathy.
References in periodicals archive ?
Louis showed that daily doses of chloroquine or hydroxychloroquine reduced insulin resistance and improved lipid metabolism, most likely via activation of the ataxia telangiectasis mutated (ATM) gene (Cell Metab.
In this study, chloroquine administration in a dose of 970 mg body weight of Wistar rats elevated serum hepatic and renal parameters.
While in chloroquine treated group bilirubin concentration was 1.
For the 12 months ended June 2011, the US brand sales for Flucytosine and Chloroquine Phosphate were about USD20m collectively, according to IMS Health data.
falciparum (IC50 = 20-100 | [mu] g/ml), in comparison to chloroquine (IC5o = 0.
Another Nigerian study showed that chloroquine was mostly used for treating severe malaria from 2000-2006 in children less than 5 years despite recommendation by the National Treatment Policy (2005) [10] to switch over to quinine and parenteral artemisinins.
One, MrgprA3, is stimulated by chloroquine, while the second, MrgprC11, is stimulated by BAM8-22, a peptide released by immune cells, including mast cells, during inflammation.
Clinicians should consider switching patients with uncomplicated, laboratory-confirmed malaria from chloroquine treatment to other recommended drugs after any indication of poor response to chloroquine such as increasing parasite density 24 hours after starting treatment, persistent parasitemia 48 hours after starting treatment, or clinical deterioration.
Parasite inoculation: The chloroquine sensitive Plasmodium berghei NK-65 strain was maintained in vivo in BALB/c mice in our laboratory by weekly inoculation of 1x[10.