The cells were incubated in dark in 96-well plates with different concentrations of the Sn(IV) chlorin e6 photosensitiser (10, 15, 20, 25 and 30 [micro]g/ml) and was not treated with light.
The dark toxicity of Sn(IV) chlorin e6 was examined and represented in Figure 2.
Figure 3 shows the effect of Sn(IV) chlorin e6 on the viability of HepG2 cancer cells at different concentrations of the photosensitizer, fixed light dose of 70 J/cm2, and 6 hours of incubation time.
The effect of Sn(IV) chlorin e6 on the viability of HepG2 was less than effect of other photosensitizers such as 5-ALA and PAD-S31 which reached 80% of phototoxicity, while this photosensitizer did not exceed 50% at the indicated concentrations and doses.
It is well known that metal-chelated porphyrin rings can be electrolytically hydrogenated first to chlorins
and thereafter desintegrated, freeing the chelated metals, such as uranium, vanadium and nickel [20, 21].
Investigations have been performed on photobleaching compounds like chlorins
and phthalocyanines in vitro and in vivo (Spikes and Bommer, 1993; Streckyte and Rotomskis, 1993).
Effects of ozon, chlorine dioxide, chlorin, and monochloramine on Cryptosporidium parvum oocyst viability, Appl, Environ Microbiol.
Alongside the well-established photosensitizers such as porphyrins, phtalocyanins and chlorins
, hypericin is a modern anticancer drug which exhibits promising photodynamic therapeutical properties.
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