Single nucleotide polymorphism-based system improves the applicability of quantitative PCR for chimerism
In the past, the drawback to using STR analysis for chimerism
quantification and monitoring was the cumbersome process of analyzing fragment data-determining fragment sizes, usually in one program, manually determining informative loci, and then transferring results to a spread sheetfor quantification and monitoring.
However, while allorecognition in Botryllus appears to be promoting highly discriminatory fusion events, to date no clear advantage to chimerism
has been documented (reviewed in Rinkevich and Weissman, 1992; De Tomaso, 2006).
Patients: Patients were evaluated in two categories:  Twenty-eight transplants with at least one-year follow-up postHSCT were evaluated for the long-term follow-up of MC, and (2) Twenty transplants within this group with chimerism
evaluation done both at the 1st month and the 3rd month postHSCT were evaluated for the evolution of early MC detected at the 1st month postHSCT.
Plasma DNA can serve as an alternative sample type for the determination of HSCT chimerism
(20) and as a potential marker for monitoring graft rejection or other sources of tissue damage after solid-organ transplantation (19, 25, 26).
Despite the full chimerism
and the presence of GVHD, an isolated extramedullary relapse after transplantation occurred in our case.
Three of ten patients were positive for the presence of CB001 cells at day 7; however, there was no chimerism
contribution from CB001 between days 21-28.
may eventually render the recipient tolerant to cell, tissue or organ transplants from the same donor, thereby enabling transplant patients to discontinue immunosuppressive medications after building stable immunological tolerance.
Origin and outcome of pregnancies affected by androgenetic/biparental chimerism
It should be remembered that although the majority of such individuals are hemizygous males, heterozygous females, depending on their chimerism
,may have G6PD deficiency in as many as 80% of their erythrocytes.
Delayed donor red cell chimerism
and pure red cell aplasia following major ABO-incompatible nonmyeloablative hematopoietic stem cell transplantation.
Genetically nonhomogenous entities can be established by chimerism
(a situation where an organism possesses cells simultaneously derived from at least two genetically distinct conspecifics) or by a mosaicism (production of an organism with genetically different cells that derived from a single zygote lineage).