Iconic's lead clinical-stage program is a novel recombinant human chimeric protein
therapeutic, hI-con1, licensed from Yale University.
The ETV6-NTRK3 gene fusion encodes a chimeric protein
tyrosine kinase that transforms NIH3T3 cells.
The chimeric protein
contains three polypeptidyl fragments: (a) a first polypeptidyl fragment at the N-terminal end of the chimeric protein
that contains a protein transduction domain (PTD) or a fragment thereof having HIV Tat PTD activity; (b) a second polypeptidyl fragment at the C-terminal end of the first polypeptidyl fragment that contains a J-domain or a fragment thereof having heat shock protein 70 (Hsp70)-interacting activity; and (c) a third polypeptidyl fragment at the C-terminal end of the second polypeptidyl fragment that contains a target protein or polypeptide.
This chimeric protein
reveals what parts of GLUT4 play a role in indinavir's inhibition of glucose absorption.
This gene fusion is postulated to produce an oncogenic chimeric protein
with the zinc finger DNA-binding domains of WT1 with the transcriptional regulatory domain of the Ewing sarcoma gene.
The high efficiency of protein expression obtained with this particular bgh-polyA signal became apparent as we subsequently documented its efficiency in a wide range of chimeric protein
expression systems, both in vivo and in vitro.
Abstract #129 "T-Cells Edited to Express CCR5 or CXCR4 Fused to the C34 Peptide from gp41 Heptad Repeat-2 Exhibit Robust Protection from Diverse HIV-1 Isolates" Wednesday, March 6, 2013 The data demonstrate potent inhibition of HIV infection in cells expressing a chimeric protein
comprising a portion of the HIV envelope fused to either the CXCR4 or CCR5 HIV co-receptors.
Although most of the autoreactive epitopes of GAD65 are located within the middle and the C-terminal regions of GAD65 (amino acids 245-585) (27, 34), truncated GAD65 lost almost all of its autoreactive epitopes when it was integrated in a chimeric protein
with IA2c (Fig.
Nasdaq National Market: NEOL) announced today publication of data on its product IL13-PE38, a chimeric protein
composed of human interleukin-13 (IL-13) and a truncated form of Pseudomonas exotoxin (PE38QQR).
Reagents for such method are provided including a mammalian cell having a plurality of steroid receptor response elements in an array such that the response element can be directly detected when bound by fluorescently labeled steroid receptor and a chimeric protein
comprising a fluorescent protein fused to a steroid receptor.
We report a technique for the preparation of densely packed monolayers of Fc-binding receptors (recombinant protein A, protein G, and chimeric protein
A/G) immobilized on the surface of silicon wafers or quartz.
The present invention provides a chimeric protein
for targeted elimination of FcRI expressing cells especially useful for the therapy of allergic responses.