chimeric


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia.
Related to chimeric: Chimeric Antibody, Chimeric DNA, Chimeric protein, chimeric gene

chi·mer·ic

(kī-mēr'ik),
1. Relating to a chimera. Compare: mosaicism.
2. Composed of parts that are of different origin and are seemingly incompatible.

chimeric

(kī-mĕr′ĭk, -mîr′-)
adj.
1. Relating to or being an organism, part, or molecule that is a chimera: chimeric mice; chimeric proteins.
2. Relating to a monoclonal antibody produced from the cells of a nonhuman organism, usually a mouse, in which a portion of the antibody has been replaced with a human sequence of amino acids. This is done in the laboratory by replacing part of the DNA sequence in the nonhuman cells with a sequence of human DNA.

chi·mer·ic

(kī-mēr'ik)
1. Relating to a chimera.
Compare: chimera (5)
2. Composed of parts that are of different origin and are seemingly incompatible.
References in periodicals archive ?
5 December 2015) Characterization and Accurate Early Prediction of Cytokine Release Syndrome After Chimeric Antigen Receptor (CAR) T cell Therapy for Acute Lymphoblastic Leukemia (ALL) [poster presentation].
DelveInsight is offering the Report on Chimeric Antigen Receptor (CAR)-T cell Immunotherapy at a price of USD 1,750 as a single user license, USD 3,500 as a site license and USD 5,000 as a Global/Enterprise License.
When the tetravalent dengue chimeric vaccine was given to partially dengue-immune children and adults in the Philippines, a broad neutralizing antibody response was observed after administration of only 2 vaccine doses (7).
Chimeric CYP21P/CYP21 and TNXA/ TNXB genes in the RCCX module.
Chimeric genes apparently form as part of a DNA-reshuffling process.
Chimeric antitumor necrosis factor-[alpha] antibodies have become an established treatment for Crohn's disease, and they should be considered for the small number of patients with severely resistant celiac disease.
The bifunctional nature of the chimeric multi-antigen vaccine technology represents a unique and direct approach in the therapy of chronic infectious diseases by specifically targeting antigen-presenting cell receptors with the most effective combination of viral antigen(s) and novel antibody tail fragment, the chimeric antigen.
This patent, US 8,921,332, covers the use of a chimeric endonuclease to induce homologous recombination between a nucleic acid vector and the chromosomal DNA of the cell in vitro to modify a specific sequence .
We report detailed molecular analyses of 100 probands who carried chimeric CYP21A1P/CYP21A2 genes.
The research, which took place at OHSU's Oregon National Primate Research Center, has also resulted in the first successful birth of chimeric monkeys - monkeys developed from stem cells taken from two separate embryos.
Fortunately, novel approaches (development of incompetent mosquitoes), development of modern tetravalent vaccines, and development of chimeric vaccine viruses (4), using classic as well as molecular approaches will soon be available and hold out promise of tools we need to eliminate or eradicate this scourge.
Ever since King Minos of Crete created a giant labyrinth beneath his palace at Knossos to confine the Minotaur, the monstrous chimeric progeny of his wife's liaison with a bull, mazes and labyrinths have exerted a powerful sway on human cultural imagination.