chief cell


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Related to chief cell: parietal cell, G cell, enteroendocrine cell, chief cell of stomach

chief cell

the predominant cell type of a gland.

chief cell

Etymology: Fr, chef; L, cella, storeroom
1 also called zymogenic cell. Any one of the columnar epithelial cells or the cuboidal epithelial cells that line the gastric glands and secrete pepsinogen and intrinsic factor, which are needed for the digestion and absorption of vitamin B12 and the normal development of red blood cells. Pernicious anemia may be caused by the absence of intrinsic factor.
2 any one of the epithelioid cells with pale-staining cytoplasm and a large nucleus containing a prominent nucleolus. Cords of such cells form the main substance of the pineal body.
3 also called principal cell. Any one of the polyhedral epithelial cells, within the parathyroid glands, which contain pale, clear cytoplasm and a vesicular nucleus.

chief cell

(chēf sel)
The predominant cell type of a gland.

chief cell

1. Any of the cells of the parathyroid gland that secretes the parathyroid hormone.
2. Any of the cells of the gastric glands that secretes pepsinogen.
See also: cell
References in periodicals archive ?
The strong cytoplasmic staining of PTH in chief cells is readily identifiable.
Microscopic examination of the biopsy specimen of the left inferior parathyroid gland showed only chief cells.
If a significant injury is introduced in cell cultures or in animal models, more chief cells become stem cells, making it possible to fix the damage.
Paragangliomas are composed of two cell types: chief cells and sustentacular cells.
Immunohistochemistry confirmed the presence of 2 cell populations: the chief cells stained with neuron-specific enolase and chromogranin, whereas the sustentacular cells stained with S100 protein.
Histologically, these tumors appear highly vascular and are composed of clusters (Zellballen, which is German for "cell balls") of chief cells supported by sustentacular cells and small blood vessels.