chenodeoxycholic acid


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chenodeoxycholic acid

 [ke″no-de-ok″se-ko´lic]
one of the primary bile acids in humans, usually found conjugated with glycine or taurine; it facilitates fat absorption and cholesterol excretion. The pharmaceutical preparation, called chenodiol, is used in treatment of gallstones.

che·no·de·ox·y·cho·lic ac·id

(kē'nō-dē-oks'ē-kō'lik as'id),
A major bile acid in many vertebrates, usually conjugated with glycine or taurine; it facilitates cholesterol excretion and fat absorption; administered to dissolve cholesterol gallstones.
Synonym(s): chenodiol

chenodeoxycholic acid

/che·no·de·oxy·cho·lic ac·id/ (ke″no-de-ok″se-kol´ik) a primary bile acid, usually conjugated with glycine or taurine; it facilitates fat absorption and cholesterol excretion.

chenodeoxycholic acid

[kē′nōdē·ok′sikō′lik]
a secondary bile acid. It is used in vivo to dissolve cholesterol gallstones, particularly in the elderly and poor-risk patients. See also ursodeoxycholic acid.

chenodeoxycholic acid

A bile acid with detergent properties. It has been used as a drug to dissolve GALLSTONES, but this takes 6 months to 2 years.

che·no·de·ox·y·cho·lic ac·id

(kē'nō-dē-oks'ē-kō'lik as'id)
A major bile acid in many vertebrates; facilitates cholesterol excretion and fat absorption; administered to dissolve cholesterol gallstones.

chenodeoxycholic acid

a primary bile acid, C24H40O4, administered as an anticholelithogenic agent. Called also chenodiol.
References in periodicals archive ?
Besides, the Chenodeoxycholic Acid (CAS 474-25-9) Market Research Report 2013 provides Chenodeoxycholic acid prices in regional markets.
Chenodeoxycholic acid appeared to be the most active of the bile salts, based on the results at 8 weeks, with inhibition of growth even at a 5-fold dilution (1.
The farnesoid X receptor (FXR) is a receptor for bile acids such as chenodeoxycholic acid (CDCA), deoxycholic acid, cholic acid, and their conjugates.
We also look forward to raising awareness of CTX, a rare, underdiagnosed and severe disease that is treated with chenodeoxycholic acid.
OCA is a potent, first-in-class farnesoid X receptor (FXR) agonist derived from the primary human bile acid chenodeoxycholic acid, the natural endogenous FXR agonist.
INT-747 (obeticholic acid) is a potent, first-in-class FXR agonist that is a small molecule bile acid derivative of chenodeoxycholic acid (CDCA), a primary human bile acid and natural endogenous FXR agonist.
INT-747 is a potent, first-in-class farnesoid X receptor (FXR) agonist derived from the primary human bile acid chenodeoxycholic acid (CDCA), the natural endogenous FXR agonist.