chenodeoxycholic acid


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chenodeoxycholic acid

 [ke″no-de-ok″se-ko´lic]
one of the primary bile acids in humans, usually found conjugated with glycine or taurine; it facilitates fat absorption and cholesterol excretion. The pharmaceutical preparation, called chenodiol, is used in treatment of gallstones.

che·no·de·ox·y·cho·lic ac·id

(kē'nō-dē-oks'ē-kō'lik as'id),
A major bile acid in many vertebrates, usually conjugated with glycine or taurine; it facilitates cholesterol excretion and fat absorption; administered to dissolve cholesterol gallstones.
Synonym(s): chenodiol

chenodeoxycholic acid

/che·no·de·oxy·cho·lic ac·id/ (ke″no-de-ok″se-kol´ik) a primary bile acid, usually conjugated with glycine or taurine; it facilitates fat absorption and cholesterol excretion.

chenodeoxycholic acid

[kē′nōdē·ok′sikō′lik]
a secondary bile acid. It is used in vivo to dissolve cholesterol gallstones, particularly in the elderly and poor-risk patients. See also ursodeoxycholic acid.

chenodeoxycholic acid

A bile acid with detergent properties. It has been used as a drug to dissolve GALLSTONES, but this takes 6 months to 2 years.

che·no·de·ox·y·cho·lic ac·id

(kē'nō-dē-oks'ē-kō'lik as'id)
A major bile acid in many vertebrates; facilitates cholesterol excretion and fat absorption; administered to dissolve cholesterol gallstones.

chenodeoxycholic acid

a primary bile acid, C24H40O4, administered as an anticholelithogenic agent. Called also chenodiol.
References in periodicals archive ?
Chenodeoxycholic acid appeared to be the most active of the bile salts, based on the results at 8 weeks, with inhibition of growth even at a 5-fold dilution (1.
We have demonstrated that the bile acids chenodeoxycholic acid, deoxycholic acid and cholic acid, alone or in combination, at physiological concentrations, inhibit the growth of MTB in vitro.
Its product offering includes Chenoda, a chenodeoxycholic acid used for the treatment of patient suffering from gallstones and cerebrotendinous xanthomatosis (CTX), and Vecamyl, or mecamylamine tablets, for management of moderately severe to severe essential hypertension.
The farnesoid X receptor (FXR) is a receptor for bile acids such as chenodeoxycholic acid (CDCA), deoxycholic acid, cholic acid, and their conjugates.
Chenodeoxycholic acid was purchased from Sigma-Aldrich (St.
Potential bile acid precursors in plasma-possible indicators of biosynthetic pathways to cholic and chenodeoxycholic acids in man.
Oral administration of UDCA in humans leads to a significant change in the relative proportions of the biliary and serum bile acids, such that UDCA becomes the major bile constituent (about 50 percent when a 13-15 mg/kg/day dose is given) and naturally replaces cholic and chenodeoxycholic acids.