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chenodeoxycholic acid

   Also found in: Acronyms, Encyclopedia, Wikipedia 0.01 sec.
chenodeoxycholic acid /che·no·de·oxy·cho·lic ac·id/ (ke″no-de-ok″se-kol´ik) a primary bile acid, usually conjugated with glycine or taurine; it facilitates fat absorption and cholesterol excretion.
chenodeoxycholic acid
[kē′nōdē·ok′sikō′lik]
a secondary bile acid. It is used in vivo to dissolve cholesterol gallstones, particularly in the elderly and poor-risk patients. See also ursodeoxycholic acid.

chenodeoxycholic acid
a primary bile acid, C24H40O4, administered as an anticholelithogenic agent. Called also chenodiol.


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Short of surgery, the only gallstone therapy currently approved in the United States is treatment with chenodeoxycholic acid.
Oral administration of UDCA in humans leads to a significant change in the relative proportions of the biliary and serum bile acids, such that UDCA becomes the major bile constituent (about 50 percent when a 13-15 mg/kg/day dose is given) and naturally replaces cholic and chenodeoxycholic acids.
 
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