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chenodeoxycholic acid |
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chenodeoxycholic acid /che·no·de·oxy·cho·lic ac·id/ (ke″no-de-ok″se-kol´ik) a primary bile acid, usually conjugated with glycine or taurine; it facilitates fat absorption and cholesterol excretion. chenodeoxycholic acid [kē′nōdē·ok′sikō′lik] a secondary bile acid. It is used in vivo to dissolve cholesterol gallstones, particularly in the elderly and poor-risk patients. See also ursodeoxycholic acid. chenodeoxycholic acid a primary bile acid, C24H40O4, administered as an anticholelithogenic agent. Called also chenodiol. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Short of surgery, the only gallstone therapy currently approved in the United States is treatment with chenodeoxycholic acid. Oral administration of UDCA in humans leads to a significant change in the relative proportions of the biliary and serum bile acids, such that UDCA becomes the major bile constituent (about 50 percent when a 13-15 mg/kg/day dose is given) and naturally replaces cholic and chenodeoxycholic acids. |
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