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chemotherapy-induced emesis

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chemotherapy-induced emesis
Chemotherapy-induced nausea & vomiting Oncology A side effect of many chemotherapeutic agents which, while often the most anxiety-provoking of the toxic effects of chemotherapy, is self-limited and rarely life-threatening Highly emetogenic Cisplatin, carmustine, dacarbazine, dactinomycin, mechlorethamine–nitrogen mustard, streptozocin Management Dopamine D2 high-dose metoclopramide, serotonin–5-HT3 receptor antagonists–eg, ondansetron. See Ondansetron.


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This research has led to a number of evidence-based pharmacological options to manage post-operative or chemotherapy-induced emesis (anticholingerics, phenothiazines, antihistamines, benzamines and serotonin receptor antagonists), but it is not known how effectively or safely these anti-emetic drugs might be applied to the pregnant population (Kovac, 2000; Habib et al, 2004; Vayrat-Follet et a1,1997).
MK-869, a substance P antagonist compound moving into Phase III research for chemotherapy-induced emesis.
the substance P program for depression and chemotherapy-induced emesis, and other compounds for bacterial infections, asthma, several types of cancer, and infant diarrhea.
 
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