chemotherapeutic index


Also found in: Dictionary, Thesaurus, Legal, Financial, Encyclopedia, Wikipedia.

che·mo·ther·a·peu·tic in·dex

the ratio of the minimal effective dose of a chemotherapeutic agent to the maximal tolerated dose. Originally used by Ehrlich to express the relative toxicity of a chemotherapeutic agent to a parasite and to its host.

chemotherapeutic index

a system for judging the safety and effectiveness of a drug as a ratio between the dose that is lethal to 50% of animals (LD50) and the median effective (ED50) or minimal curative dose.

che·mo·ther·a·peu·tic in·dex

(kē'mō-thār'ă-pyū'tik in'deks)
The ratio of the minimal effective dose of a chemotherapeutic agent to the maximal tolerated dose. Originally used by Ehrlich to express the relative toxicity of a chemotherapeutic agent to a parasite and to its host.

chemotherapeutic index

The ratio of the toxicity of a drug, expressed as the maximum tolerated dose per kilogram of body weight to the minimal curative dose per kilogram of body weight. This index is used in judging the safety and effectiveness of drugs.
See also: index