Any of several compounds that inhibit the functioning of a particular cellular glycoprotein and make cells, especially tumor cells, sensitive to chemotherapeutic agents.
References in periodicals archive ?
This study will give us the additional information on the utility of burixafor as a chemosensitizer in combination with chemotherapy and could greatly expand the indications and increase the market potential in hematology/oncology.
Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs.
CHQ also has potential for use as a chemosensitizer in cancer in conjunction with some conventional antineoplastic agents.
In preclinical studies, OGX-427 has shown to significantly reduce levels of Hsp27, induce apoptosis in several cancer cell lines, has single agent anti-tumour activity, and acts as a chemosensitizer with several cytotoxic drugs, including docetaxel.
Synthetic lethal screen identification of chemosensitizer loci in cancer cells.
AB Science is developing masitinib in veterinary medicine in oncology, including several studies to further investigate masitinib's potential as a chemosensitizer, as well as in non oncology diseases, such as canine atopic dermatitis or asthma in cats.
In vivo evidence of gamma-tocotrienol as a chemosensitizer in the treatment of hormone-refractory prostate cancer.
Preclinical studies at the Prostate Centre at Vancouver General Hospital show that OGX-427 significantly decreases levels of Hsp27, induces apoptosis in several human cancer cell lines, has single agent anti-tumor activity, and acts as a chemosensitizer with several cytotoxic drugs, including docetaxel.
III) The extent of the interaction between a chemosensitizer (A) and a chemotherapeutical agent (B) was illustrated using an isobologram.
Naughton said there are also other cancer types for which phenoxodiol has shown promise and the Company would be proceeding in the year ahead with a strategy to expand the drug's utility into those other cancers as both a chemosensitizer and as a monotherapy.
FDA in the second half of 2007, and with Canadian and European regulators in 2008; AnorMED's expectation that it will present additional data relating to MOZOBIL at the ASH conference to be held in Orlando, Florida from December 8 to 12, 2006; AnorMED's expectation that it will initiate clinical studies for MOZOBIL for use as a chemosensitizer for treatment of leukemia patients; and AnorMED's expectation that it can clinically develop its second product, AMD070, now in Phase I/II clinical trials in HIV patients.
AB Science SA (Paris:AB) (NYSE-Euronext - FR0010557264 - AB), a pharmaceutical company specializing in the research, development and commercialization of protein kinase inhibitors (PKIs), announces publication in The Veterinary Journal of results from a preclinical study showing that masitinib has potential as a chemosensitizer.