chemoresistance

(redirected from chemoresistant)

che·mo·re·sis·tance

(kē'mō-rē-zis'tants),
The resistance of bacteria or malignant cells to the inhibiting action of certain chemical substances used in treatment.

chemoresistance

/che·mo·re·sis·tance/ (-re-zis´tans) specific resistance acquired by cells to the action of certain chemicals.

chemoresistance

1 a specific resistance by components of a cell to chemical substances.
2 the resistance of bacteria or a cancer cell to a chemical designed to treat the disorder.

chemoresistance

1. Resistance of cells to the action of a specific therapeutic agent.
2. Resistance of a particular tumor to chemotherapy; treatment refractory.

che·mo·re·sis·tance

(kē'mō-rē-zis'tăns)
The state of being resistant to a chemical.
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References in periodicals archive ?
There are limited options for treatment with cytotoxic regimens as prostate cancer is a highly chemoresistant malignancy.
11) Similarly, activation of the anaplastic lymphoma kinase (ALK) signal transducer and activator of transcription 3 (STAT3) pathway is also able to induce PD-L1 expression in ALK-carrying T-cell lymphoma and chemoresistant non-small cell lung cancer (NSCLC).
Successful treatment of a chemoresistant tumor with temozolomide in an adult patient: report of a recurrent intracranial mesenchymal chondrosarcoma.
Previous reports indicate that the ginger component 6-shogaol induces cell death in chemoresistant hepatoma cells and induce activity against breast cancer.
New chemoresistant cancer cells thrive in immunosuppressed environments and travel through the blood with ease to initiate cancer cell metastasis.
Particularly, AB23 showed remarkable activity on the paditaxel-resistant ovarian cancer A2780 cells, indicating that it might be used for treatment of chemoresistant ovarian cancer.
Accordingly, two therapeutic strategies were currently used in the clinical trials: One was to inhibit the cytoprotective function of autophagy to improve the killing efficacy of chemotherapy drugs or resensitize the chemoresistant tumor cells to drugs; the other was to induce autophagic cell death in the apoptosis-defective tumor cells, which showed high resistance to apoptosis by activating autophagic pathways.
The selective inhibition of nuclear PKCzeta restores the effectiveness of chemotherapeutic agents in chemoresistant cells," Cell Cycle, vol.
Besides difficulty in diagnosis, the treatment regimens, duration, drug combinations, drug efficacy assessment, treatment end-points criteria are largely debatable subjects and the probable causes of the recent resurgence of chemoresistant mycobacterium TB.
One of the two non-resistant lines and its resistant clone were deficient in their DNA mismatch repair systems, which results in genetic instability, increased susceptibility to neoplastic transformation, and greater development of chemoresistant cells.
Background: To investigate the role of a topoisomerase I inhibitor (topotecan) in chemoresistant ovarian cancer-initiating cells.
Several novel agents are now in clinical trials in patients with chemoresistant breast cancer, including rucaparib, an oral small-molecule inhibitor of PARP (poly ADP-ribose polymerase), for triple-negative breast cancer; palbociclib, an oral and selective inhibitor of cyclin dependent kinases 4 and 6, in women with hormone receptor-positive / HER2-negative disease; and trastuzumab emtansine, a conjugate of trastuzum ab and the cytotoxic agent mertansine, in patients with chemoresistant HER2-positive breast cancer, Dr.