Debio 1143 has shown a favorable safety profile in a dose-finding and efficacy Phase I/II trial in combination with chemoradiotherapy
in squamous cell carcinoma of the head and neck (Debio 1143-201).
One received concurrent chemoradiotherapy
and was alive with no evidence of disease at 39 months following his primary surgery.
Finally, primary cisplatin-based chemoradiotherapy
was recommended as the best current treatment of it (9, 10).
In 2015, a Japanese medical team published a study indicating that the adenocarcinoma component of esophageal cancer is more stubbornly resistant to chemoradiotherapy
than the squamous component of esophageal cancer.
The company s decision to discontinue the current clinical program in NSCLC, which includes the Phase III START2 and INSPIRE studies, follows recent results from a planned analysis of EMR 63325-009, a randomized, double-blind, placebo-controlled Phase I/II study in Japanese patients with Stage III unresectable, locally advanced NSCLC who had received concurrent or sequential chemoradiotherapy
(CRT), with a minimum of two cycles of platinum-based chemotherapy and radiation dose ?
The prognosis for the treatment of this type of cancer with radiotherapy and chemoradiotherapy
Low level laser therapy for concurrent chemoradiotherapy
induced oral mucositis in head and neck cancer patients-atriple blinded randomized controlled trial.
The 5 year overall survival rate was 48% in the chemoradiotherapy
+ radiotherapy group and 35% in the radiotherapy group.
Evaluation of nonenhancing tumor fraction assessed by dynamic contrast-enhanced MRI subtraction as a predictor of decrease in tumor volume in response to chemoradiotherapy
in advanced cervical cancer.
Prognostic impact of H3K27me3 expression on loco regional progression after chemoradiotherapy
in esophageal squamous cell carcinoma.
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) after high-dose marrow-ablative chemoradiotherapy
is an effective treatment method in various hematologic, neoplastic, and congenital disorders.
The aim of our study was to determine whether the apparent diffusion coefficient (ADC) values could be used as a reliable detector of response in carcinoma of the cervix treated with chemoradiotherapy
as compared with conventional morphological MRI response.