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che·mo·kines (CC),

Several groups composed of usually 8-10 kD polypeptide cytokines that are chemokinetic and chemotactic, stimulating leukocyte movement and attraction.
Synonym(s): intercrines
[chemo- + G. kineō, to set in motion]


Several groups composed of usually 8-10 kD polypepytide cytokines that are chemokinetic and chemotactic stimulating leukocyte movement and attraction.
Synonym(s): intercrines.
[chemo- + G. kineō, to set in motion]


Chemotactic CYTOKINES, a family of about 50 structurally-related heparin-binding proteins that can induce activation and migration of specific types of white cell, attracting them to sites of inflammation by chemotaxis. They have a fundamental role in inflammation and are concerned in the immune system protective responses to infecting organisms. Chemokines are also concerned in ANGIOGENESIS. Chemokines are implicated in allergic rhinitis, rheumatoid arthritis, asthma, atherosclerosis, inflammatory bowel disease, COPD, insulin resistance, obesity-induced diabetes, multiple sclerosis and psoriasis. Chemokine-receptor antagonists are under active investigation.


a large family of chemotactic cytokines which stimulate leukocyte movement.
References in periodicals archive ?
The production of chemokines (TARC, MDC, RANTES, and 1L-8) was quantified in the supernatant using an ELISA kit specific for that chemokine (all from R&D Systems Inc.
Ransohoff's team has shown that chemokines also may help determine whether a nervous system damaged by MS can repair itself.
These findings give insight into mechanisms of fetal-maternal immune tolerance, as well as reveal the epigenetic modification of chemokine genes within tissue stromal cells as a modality for limiting the trafficking of activated T cells," Dr.
While antagonists to P-selectin and glycoprotein IIb/IIa, which play an essential role in the initial recruitment ofwhite blood cells, did nothing to reduce edema and tissue destruction, both CT-2009 and antibodies to the platelet-derived chemokines CCL5 and CXCL4 diminished neutrophil recruitment and reduced edema and tissue damage.
Interpretation & conclusions: Our findings showed that cellular as well as humoral immunity are critical in MRSA infection and that T cell activation and the increase in chemokines may play a role in the regulation of immune response.
Muller and Zlotnik have shown that antibodies designed to block interactions between chemokines and their receptors on white blood cells reduce the spread of breast cancer cells to lymph nodes and lung tissue in mice.
No differences in maternal chemokines were detected at baseline or after the supplementation, and there were no significant differences between the placebo, EPA-rich, and DHA-rich groups.
All of these organs house macrophages, phagocyte immune cells that secrete chemokines and cytokines, the signaling molecules that coordinate the overall immune response.
Opening with a general introduction on chemokine function and chemokine receptor biology, the handbook goes on to cover the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including HIV/AIDS.
Diaz speculates that the chemokine receptor plays a role in the immune response to wart-causing human papilloma virus.
Chemokines are classified into three subfamilies [alpha], [beta] and [gamma] based on the position of four cysteine residues that form disulphide bonds.
The researchers, however, concede that existing small molecules that bind to chemokines only bind weakly, and thus are not good candidates for use in medicines.