chemokine receptor


Also found in: Dictionary, Thesaurus, Legal, Financial, Encyclopedia, Wikipedia.
Related to chemokine receptor: Chemokines

chemokine receptor

Abbreviation: CCR
Any of several protein receptors for chemokines that spans the cell membrane and links to intracellular G proteins. The cell-to-cell signaling and regulating effects of chemokines, e.g., on inflammation or hematopoiesis, are mediated through chemokine receptors, which can be blocked with specific antagonist drugs. CCR5 and CXCR4 are chemokine receptors that are also receptors for HIV. The virus uses these receptors to gain entry into T cells, macrophages, and other CD4+ cells.
See also: receptor

Chemokine receptor

A receptor on the surface of some types of immune cells that helps to mediate entry of HIV into the cell.
Mentioned in: AIDS
References in periodicals archive ?
2007) has proposed that leishmaniasis patients with mucocutaneous lesions present a stronger T-cell response and that delta32 carriers could have a weaker inflammatory immune response and migratory capacity due to the non-functional chemokine receptor.
Since the normal function of the chemokine receptors used by HIV-I for entry is to activate cells in response to various stimuli, he hypothesized that the virus itself (or its envelope glycoprotein gp120 that mediates attachment to cells) might mimic natural activation signals and he responsible for inflammation and injury in organs like brain and lung where macrophages are infected and also activated.
In order to better understand the early events on the host-parasite interactions, in this paper, we evaluated the production of proinflammatory (IFN-[gamma], IL-12p70, CCL3, CCL4, CCL5, CXCL10) and of anti-inflammatory (IL-10, IL-13) cytokines, chemokines and chemokine receptors taking advantage of the in vitro priming system using peripheral blood mononuclear cells (PBMCs) from healthy individuals stimulated by live promastigotes of L.
Although other chemokine receptors have been identified that can facilitate HIV infection in vitro (7), it is now well recognized that only CCR5 and CXCR4 are the critical coreceptors for HIV infection in vivo.
Diaz speculates that the chemokine receptor plays a role in the immune response to wart-causing human papilloma virus.
The report provides comprehensive information on the C-C Chemokine Receptor Type 1 (HM145 or LD78 Receptor or Macrophage Inflammatory Protein 1-Alpha Receptor or CD191 or CCR1), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation.
Although it's classified as a chemokine receptor, CCR5 also serves an infamous function.
Direct infection of arterial smooth muscle cells appears to augment expression of the CMV chemokine receptor US28 (69).
Emerging therapies with different mechanisms of actionincluding the interleukin (IL)-12/IL-23 inhibitor ustekinumab (Janssen Biotech/Janssen Cilag's Stelara), the cell adhesion molecule (CAM) inhibitor vedolizumab (Millennium Pharmaceuticals), and the chemokine receptor inhibitor GSK-1605786 (formerly Traficet-EN or CCX-282B; GlaxoSmithKline/ChemoCentryx)are in clinical development for CD.
Global Markets Direct's, 'C-X-C Chemokine Receptor Type 1 (CDw128a or High Affinity Interleukin-8 Receptor A or IL-8 Receptor Type 1 or CD181 or CXCR1) - Pipeline Review, H1 2016', provides in depth analysis on C-X-C Chemokine Receptor Type 1 (CDw128a or High Affinity Interleukin-8 Receptor A or IL-8 Receptor Type 1 or CD181 or CXCR1) targeted pipeline therapeutics.
The product is a new, potent and selective chemokine receptor antagonist that has beendiscovered by the company.