chemokine receptor


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Related to chemokine receptor: Chemokines

chemokine receptor

Abbreviation: CCR
Any of several protein receptors for chemokines that spans the cell membrane and links to intracellular G proteins. The cell-to-cell signaling and regulating effects of chemokines, e.g., on inflammation or hematopoiesis, are mediated through chemokine receptors, which can be blocked with specific antagonist drugs. CCR5 and CXCR4 are chemokine receptors that are also receptors for HIV. The virus uses these receptors to gain entry into T cells, macrophages, and other CD4+ cells.
See also: receptor

Chemokine receptor

A receptor on the surface of some types of immune cells that helps to mediate entry of HIV into the cell.
Mentioned in: AIDS
References in periodicals archive ?
Expression of chemokine receptors CXCR4 and CCR5 in HIV-1-infected and uninfected individuals.
CXC chemokine receptor 4 expression and function in human anaplastic thyroid cancer cells.
A deletion in the chemokine receptor 5 (CCR5) gene is associated with tickborne encephalitis.
The CC chemokine receptor 5 (CCR5) delta 32 variant results in a non-functional form of the chemokine receptor, which is incapable of binding beta chemokines (RANTES, MIP-1alpha, MIP-1beta).
Although other chemokine receptors have been identified that can facilitate HIV infection in vitro (7), it is now well recognized that only CCR5 and CXCR4 are the critical coreceptors for HIV infection in vivo.
In addition, some strains of HIV-1 can use a variety of other chemokine receptors in studies in vitro, however it does not appear that they have major relevance to HIV infection in vivo and pathogenesis.
It is a short peptide that functions as a high-affinity antagonist for CXCR4, a chemokine receptor that is directly involved in tumor progression, angiogenesis (growth of new blood vessels in the tumor), metastasis (spread of the disease to other organs or organ parts) and cell survival.
Isolating the CXCR7 receptor from potential interference by other chemokine receptors (such as the related receptor known as CXCR4), researchers demonstrated that CXCR7 cells formed significantly larger tumors in breast and lung cancer models.
Segal notes that other kinds of cancers, such as kidney tumors, also appear to depend on the chemokine receptor CXCR4 and so might also be thwarted by drugs blocking it.
Title: Rapid Mobilization Of CD34+ Stem Cells With TG-0054, a Novel CXC Chemokine Receptor 4 (CXCR4) Antagonist Session Name: 711.
a clinical-stage biopharmaceutical company focused on discovering, developing and commercializing orally-administered therapeutics that target the chemokine system, presented data today from the company's Phase 2 clinical trial of Traficet-EN(R) (CCX282-B), an orally-active anti-inflammatory agent that targets the chemokine receptor CCR9.
Rockville, MD) has patented human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques.