CCR4

(redirected from chemokine (C-C) receptor 4)

CCR4

A gene on chromosome 3p24 that encodes a G protein-coupled receptor for C-C-type chemokines (MIP-1, RANTES, TARC and MCP-1). CCR4 is a high-affinity receptor for the C-C-type chemokines CCL17/TARC and CCL22/MDC; its activity is mediated by Gi proteins, which activate phosphatidylinositol-calcium second messengers.
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