chemokine


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Related to chemokine: cytokine, interleukin, Chemokine receptor

chemokine

/che·mo·kine/ (ke´mo-kīn) any of a group of low molecular weight cytokines identified on the basis of their ability to induce chemotaxis or chemokinesis in leukocytes (or in particular populations of leukocytes) in inflammation.

chemokine

(kē′mō-kīn′, kĕm′ō-)
n.
Any of various cytokines produced in acute and chronic inflammation that mobilize and activate white blood cells.

chemokine

[kē′mōkīn]
Etymology: Gk, chemeia, alchemy + kinēsis, movement
any of a group of low-molecular-weight cytokines, such as interleukin-8, identified on the basis of their ability to induce chemotaxis or chemokinesis in leukocytes (or in particular populations of leukocytes) in inflammation. The group is divided into four subgroups on the basis of genetic, structural, and functional criteria. They function as regulators of the immune system and may also play roles in the circulatory and central nervous systems. See also cytokine.

CCL1

A gene on chromosome 17q12 that encodes a protein structurally related to the CXC subfamily of cytokines, which are characterised by two cysteines separated by a single amino acid. CCL1 is secreted by activated T cells and is chemotactic for monocytes but not neutrophils; it binds to chemokine receptor CCR8.
References in periodicals archive ?
We observed that T cells were absent from the part of the tumour containing the cancer cells that were coated with chemokine, and the principal source of the chemokine was the CAFs," said Professor Fearon.
Title: Rapid Mobilization Of CD34+ Stem Cells With TG-0054, a Novel CXC Chemokine Receptor 4 (CXCR4) Antagonist Session Name: 711.
Ransohoff considers himself lucky to have "tripped over" this discovery, which introduced him to the relatively new field of chemokine study.
CCX354 has been shown to be a potent and selective antagonist of CCR1, a chemokine receptor that drives the recruitment of certain inflammatory cells including populations of monocytes, macrophages and T cells into the joints of patients with RA.
In studies looking at chemokine receptor expression and function in osteosarcoma cell lines and tissues from osteosarcoma patients, the results showed that messenger RNA (mRNA) and protein expression of CXCR4 were correlated with neoplastic progression, in line with other solid tumors.
Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.
Chemokines are small proteins in the cytokine family that bind to chemokine receptors promoting a large number of functions among which, more importantly, the development and homeostasis of the immune system, the cellular movement by chemotaxis, the stem cell survival, the angiogenesis.
Isolating the CXCR7 receptor from potential interference by other chemokine receptors (such as the related receptor known as CXCR4), researchers demonstrated that CXCR7 cells formed significantly larger tumors in breast and lung cancer models.
Room 207 Detailed results from ChemoCentryx's Phase 2 randomized clinical trial will be provided in an oral presentation (#1031) titled "CCX282-B, an orally active inhibitor of chemokine receptor CCR9, shows anti-inflammatory and clinical activity in the treatment of Crohn's Disease" by Satish Keshav, M.
Hassan Salari, President and CEO of Chemokine Therapeutics.
Stelic's Stem Cell Dynamism Research Team has shown that hepatic cord regeneration in acute liver cell damage is regulated at the in vivo level by a protein called chemokine CXCL10.
The mutation that has been implicated in West Nile disease susceptibility shuts down the production of a protein called chemokine receptor-5 (CCR5).

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